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. 2018 Jun 21;14(6):e1007021.
doi: 10.1371/journal.ppat.1007021. eCollection 2018 Jun.

Why is a functional PHO pathway required by fungal pathogens to disseminate within a phosphate-rich host: A paradox explained by alkaline pH-simulated nutrient deprivation and expanded PHO pathway function

Sophie Lev  1   2   3 , Julianne Teresa Djordjevic  1   2   3
Affiliations

Why is a functional PHO pathway required by fungal pathogens to disseminate within a phosphate-rich host: A paradox explained by alkaline pH-simulated nutrient deprivation and expanded PHO pathway function

Sophie Lev et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Gene ontology (GO) analysis of Pho4-dependent genes in Saccharomyces cerevisiae, Candia albicans, Candida glabrata, and Cryptococcus neoformans.
The core regulatory machinery of the PHO pathway consisting of the CDK complex and the transcription factor Pho4 is conserved across the fungal species shown. However, evidence of Pho2 coregulation is absent in the fungal pathogens analysed. Pho4-dependent genes were assigned to GO groups with only the most abundant groups displayed in the analysis. Data for the comparison were assembled from Ogawa, 2000 (S. cerevisiae) [6]; Ikeh, 2016 (C. albicans) [7]; He, 2017 (C. glabrata) [8]; and Toh-e, 2015 (C. neoformans) [9]. GO annotation for C. neoformans JEC21 is publicly available at http://www.uniprot.org/uniprot/?query=jec21&sort=score and https://genome.jgi.doe.gov/Cryne_JEC21_1/Cryne_JEC21_1.home.html. Phosphate homeostasis-related genes in C. neoformans (blue) were manually annotated based on S. cerevisiae GO groups. GO groups in common are color coded. Note for C. neoformans that “transmembrane transport” is a child GO term for “transport” emphasizing the role of Pho4-dependent nutrient transport in this pathogen.
See this image and copyright information in PMC

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