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Meta-Analysis
. 2018 Jun 21;6(6):CD010583.
doi: 10.1002/14651858.CD010583.pub4.

Prophylactic abdominal drainage for pancreatic surgery

Wei Zhang  1 , Sirong He, Yao Cheng, Jie Xia, Mingliang Lai, Nansheng Cheng, Zuojin Liu
Affiliations
Meta-Analysis

Prophylactic abdominal drainage for pancreatic surgery

Wei Zhang et al. Cochrane Database Syst Rev. .

Update in

Abstract

Background: The use of surgical drains has been considered mandatory after pancreatic surgery. The role of prophylactic abdominal drainage to reduce postoperative complications after pancreatic surgery is controversial.

Objectives: To assess the benefits and harms of routine abdominal drainage after pancreatic surgery, compare the effects of different types of surgical drains, and evaluate the optimal time for drain removal.

Search methods: For the last version of this review, we searched CENTRAL (2016, Issue 8), and MEDLINE, Embase, Science Citation Index Expanded, and Chinese Biomedical Literature Database (CBM) to 28 August 2016). For this updated review, we searched CENTRAL, MEDLINE, Embase, Science Citation Index Expanded, and CBM from 2016 to 15 November 2017.

Selection criteria: We included all randomized controlled trials that compared abdominal drainage versus no drainage in people undergoing pancreatic surgery. We also included randomized controlled studies that compared different types of drains and different schedules for drain removal in people undergoing pancreatic surgery.

Data collection and analysis: We identified six studies (1384 participants). Two review authors independently identified the studies for inclusion, collected the data, and assessed the risk of bias. We performed the meta-analyses using Review Manager 5. We calculated the risk ratio (RR) for dichotomous outcomes and the mean difference (MD) for continuous outcomes with 95% confidence intervals (CI). For all analyses, we used the random-effects model.

Main results: Drain use versus no drain useWe included four studies with 1110 participants, who were randomized to the drainage group (N = 560) and the no drainage group (N = 550) after pancreatic surgery. There was little or no difference in mortality at 30 days between groups (1.5% with drains versus 2.3% with no drains; RR 0.78, 95% CI 0.31 to 1.99; four studies, 1055 participants; moderate-quality evidence). Drain use probably slightly reduced mortality at 90 days (0.8% versus 4.2%; RR 0.23, 95% CI 0.06 to 0.90; two studies, 478 participants; moderate-quality evidence). We were uncertain whether drain use reduced intra-abdominal infection (7.9% versus 8.2%; RR 0.97, 95% CI 0.52 to 1.80; four studies, 1055 participants; very low-quality evidence), or additional radiological interventions for postoperative complications (10.9% versus 12.1%; RR 0.87, 95% CI 0.79 to 2.23; three studies, 660 participants; very low-quality evidence). Drain use may lead to similar amount of wound infection (9.8% versus 9.9%; RR 0.98 , 95% CI 0.68 to 1.41; four studies, 1055 participants; low-quality evidence), and additional open procedures for postoperative complications (9.4% versus 7.1%; RR 1.33, 95% CI 0.79 to 2.23; four studies, 1055 participants; low-quality evidence) when compared with no drain use. There was little or no difference in morbidity (61.7% versus 59.7%; RR 1.03, 95% CI 0.94 to 1.13; four studies, 1055 participants; moderate-quality evidence), or length of hospital stay (MD -0.66 days, 95% CI -1.60 to 0.29; three studies, 711 participants; moderate-quality evidence) between groups. There was one drain-related complication in the drainage group (0.2%). Health-related quality of life was measured with the pancreas-specific quality-of-life questionnaire (FACT-PA; a scale of 0 to 144 with higher values indicating a better quality of life). Drain use may lead to similar quality of life scores, measured at 30 days after pancreatic surgery, when compared with no drain use (105 points versus 104 points; one study, 399 participants; low-quality evidence). Hospital costs and pain were not reported in any of the studies.Type of drainWe included one trial involving 160 participants, who were randomized to the active drain group (N = 82) and the passive drain group (N = 78) after pancreatic surgery. An active drain may lead to similar mortality at 30 days (1.2% with active drain versus 0% with passive drain; low-quality evidence), and morbidity (22.0% versus 32.1%; RR 0.68, 95% CI 0.41 to 1.15; low-quality evidence) when compared with a passive drain. We were uncertain whether an active drain decreased intra-abdominal infection (0% versus 2.6%; very low-quality evidence), wound infection (6.1% versus 9.0%; RR 0.68, 95% CI 0.23 to 2.05; very low-quality evidence), or the number of additional open procedures for postoperative complications (1.2% versus 7.7%; RR 0.16, 95% CI 0.02 to 1.29; very low-quality evidence). Active drain may reduce length of hospital stay slightly (MD -1.90 days, 95% CI -3.67 to -0.13; one study; low-quality evidence; 14.1% decrease of an 'average' length of hospital stay). Additional radiological interventions, pain, and quality of life were not reported in the study.Early versus late drain removalWe included one trial involving 114 participants with a low risk of postoperative pancreatic fistula, who were randomized to the early drain removal group (N = 57) and the late drain removal group (N = 57) after pancreatic surgery. There was no mortality in either group. Early drain removal may slightly reduce morbidity (38.6% with early drain removal versus 61.4% with late drain removal; RR 0.63, 95% CI 0.43 to 0.93; low-quality evidence), length of hospital stay (MD -2.10 days, 95% CI -4.17 to -0.03; low-quality evidence; 21.5% decrease of an 'average' length of hospital stay), and hospital costs (MD -EUR 2069.00, 95% CI -3872.26 to -265.74; low-quality evidence; 17.0% decrease of 'average' hospital costs). We were uncertain whether early drain removal reduced additional open procedures for postoperative complications (0% versus 1.8%; RR 0.33, 95% CI 0.01 to 8.01; one study; very low-quality evidence). Intra-abdominal infection, wound infection, additional radiological interventions, pain, and quality of life were not reported in the study.

Authors' conclusions: It was unclear whether routine abdominal drainage had any effect on the reduction of mortality at 30 days, or postoperative complications after pancreatic surgery. Moderate-quality evidence suggested that routine abdominal drainage probably slightly reduced mortality at 90 days. Low-quality evidence suggested that use of an active drain compared to the use of a passive drain may slightly reduce the length of hospital stay after pancreatic surgery, and early removal may be superior to late removal for people with low risk of postoperative pancreatic fistula.

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Conflict of interest statement

WZ: none known.

SH: none known.

YC: none known.

JX: none known.

ML: none known.

NC: none known.

ZL: none known.

Figures

1
1
Study flow diagram: 2018 review update
2
2
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies
3
3
Risk of bias summary: review authors' judgements about each risk of bias item for each included study
1.1
1.1. Analysis
Comparison 1 Drain use versus no drain use, Outcome 1 Mortality (30 days).
1.2
1.2. Analysis
Comparison 1 Drain use versus no drain use, Outcome 2 Mortality (90 days).
1.3
1.3. Analysis
Comparison 1 Drain use versus no drain use, Outcome 3 Intra‐abdominal infection.
1.4
1.4. Analysis
Comparison 1 Drain use versus no drain use, Outcome 4 Wound infection.
1.5
1.5. Analysis
Comparison 1 Drain use versus no drain use, Outcome 5 Morbidity.
1.6
1.6. Analysis
Comparison 1 Drain use versus no drain use, Outcome 6 Length of hospital stay (days).
1.7
1.7. Analysis
Comparison 1 Drain use versus no drain use, Outcome 7 Additional open procedures for postoperative complications.
1.8
1.8. Analysis
Comparison 1 Drain use versus no drain use, Outcome 8 Additional radiological interventions for postoperative complications.
2.1
2.1. Analysis
Comparison 2 Active drain versus passive drain, Outcome 1 Mortality (30 days).
2.2
2.2. Analysis
Comparison 2 Active drain versus passive drain, Outcome 2 Intra‐abdominal infection.
2.3
2.3. Analysis
Comparison 2 Active drain versus passive drain, Outcome 3 Wound infection.
2.4
2.4. Analysis
Comparison 2 Active drain versus passive drain, Outcome 4 Morbidity.
2.5
2.5. Analysis
Comparison 2 Active drain versus passive drain, Outcome 5 Length of hospital stay (days).
2.6
2.6. Analysis
Comparison 2 Active drain versus passive drain, Outcome 6 Additional open procedures for postoperative complications.
3.1
3.1. Analysis
Comparison 3 Early versus late drain removal, Outcome 1 Morbidity.
3.2
3.2. Analysis
Comparison 3 Early versus late drain removal, Outcome 2 Length of hospital stay (days).
3.3
3.3. Analysis
Comparison 3 Early versus late drain removal, Outcome 3 Hospital costs (EUR).
3.4
3.4. Analysis
Comparison 3 Early versus late drain removal, Outcome 4 Additional open procedures for postoperative complications.
4.1
4.1. Analysis
Comparison 4 Drain use versus no drain use sensitivity analysis for missing data, Outcome 1 Mortality (90 days) ‐ worst‐case scenario.
4.2
4.2. Analysis
Comparison 4 Drain use versus no drain use sensitivity analysis for missing data, Outcome 2 Mortality (90 days) ‐ best‐case scenario.
See this image and copyright information in PMC

Update of

References

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