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. 1985 Jun;4(6):1589-92.
doi: 10.1002/j.1460-2075.1985.tb03821.x.

Secondary structure of a channel-forming protein: porin from E. coli outer membranes

B Kleffel, R M Garavito, W Baumeister, J P Rosenbusch

Secondary structure of a channel-forming protein: porin from E. coli outer membranes

B Kleffel et al. EMBO J. 1985 Jun.

Abstract

Porin from Escherichia coli outer membranes has been analysed by high angle diffuse X-ray diffraction, and by attenuated total reflection infrared spectroscopy. These methods demonstrate independently that the majority of the polypeptide backbone is arranged in anti-parallel beta-pleated sheet structure. The average length of the beta-strands, which are oriented nearly normal to the membrane plane, is estimated to be 10-12 residues, independent of the method used. Although the details of strand arrangement (beta-barrels or stacked sheets) are not as yet known, porin represents the first transmembrane protein for which beta-structure has been established unequivocally.

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References

    1. Proc Natl Acad Sci U S A. 1979 Oct;76(10):5014-7 - PubMed
    1. J Mol Biol. 1983 Apr 25;165(4):701-10 - PubMed
    1. J Membr Biol. 1978 Sep 19;42(3):265-79 - PubMed
    1. J Mol Biol. 1983 Feb 25;164(2):313-27 - PubMed
    1. J Biol Chem. 1974 Dec 25;249(24):8019-29 - PubMed

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