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. 2018 Jun 22;16(1):173.
doi: 10.1186/s12967-018-1542-3.

Association of viral hepatitis and bipolar disorder: a nationwide population-based study

Lee-Won Chong  1   2 , Chih-Chao Hsu  3 , Chang-Yin Lee  4   5   6 , Ruey-Hwang Chou  7   8 , Cheng-Li Lin  9 , Kuang-Hsi Chang  10   11 , Yi-Chao Hsu  12
Affiliations

Association of viral hepatitis and bipolar disorder: a nationwide population-based study

Lee-Won Chong et al. J Transl Med. .

Abstract

Background: Bipolar disorder (BD), a type of psychiatric mood disorder, is manifested by chronic and recurrent mood fluctuations. This study aims to determine whether hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is a risk factor for BD.

Methods: A total of 48,215 patients with newly diagnosed viral hepatitis from 2000 to 2010 were identified and frequency-matched with 192,860 people without hepatitis. Both groups were followed until diagnosis with BD, withdrawal from the national health insurance program, or the end of 2011. Patients with viral hepatitis were grouped into 3 cohorts: HBV infection, HCV infection, and HBV/HCV coinfection. The association between viral hepatitis and BD were examined using Cox proportional hazards regression models.

Results: The incidence of BD was higher in HBV/HCV coinfection than in the control group, with an adjusted hazard ratio of 2.16 (95% confidence interval 1.06-4.41) when adjusted for sex, age, and comorbidity. After further adjustment, we noted that an age more than 65 years and female may be associated with an increased risk of BD in patients with chronic hepatitis B and C.

Conclusion: Viral hepatitis may be associated with increased risk of subsequent BD.

Keywords: Bipolar disorder; HBV; HCV; NHIRD.

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Figures

Fig. 1
Fig. 1
Cumulative incidence of bipolar disorders in patients with different hepatitis infection
See this image and copyright information in PMC

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References

    1. Alonso R, Aguilera A, Cordoba J, Fuertes A. Microbiological diagnosis of viral hepatitis. Enfermedades infecciosas y microbiologia clinica. 2015;33:e53–e62. doi: 10.1016/j.eimc.2014.08.002. - DOI - PubMed
    1. Shlomai A, de Jong YP, Rice CM. Virus associated malignancies: the role of viral hepatitis in hepatocellular carcinoma. Semin Cancer Biol. 2014;26:78–88. doi: 10.1016/j.semcancer.2014.01.004. - DOI - PMC - PubMed
    1. Liu CJ, Chen PJ. Updates on the treatment and outcomes of dual chronic hepatitis C and B virus infection. World J Gastroenterol. 2014;20:2955–2961. doi: 10.3748/wjg.v20.i11.2955. - DOI - PMC - PubMed
    1. Dinney CM, Zhao LD, Conrad CD, et al. Regulation of HBV-specific CD8(+) T cell-mediated inflammation is diversified in different clinical presentations of HBV infection. J Microbiol. 2015;53:718–724. doi: 10.1007/s12275-015-5314-y. - DOI - PubMed
    1. Sandler NG, Koh C, Roque A, et al. Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection. Gastroenterology 2011;141:1220–30, 30 e1–3. - PMC - PubMed

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