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Review
. 2017 Apr-Jun;16(2):140-149.
doi: 10.1590/1677-5449.011416.

A importância de reconhecer a síndrome antifosfolípide na medicina vascular

[Article in Portuguese]
Andreas Funke  1 , Adriana Danowski  2 , Danieli Castro Oliveira de Andrade  3 , Jozelia Rêgo  4 , Roger Abramino Levy  5
Affiliations
Review

A importância de reconhecer a síndrome antifosfolípide na medicina vascular

[Article in Portuguese]
Andreas Funke et al. J Vasc Bras. 2017 Apr-Jun.

Abstract
in English, Portuguese

Abstract: Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by recurrent arterial or venous thrombosis and/or gestational morbidity and by the presence of antiphospholipid antibodies. It can also cause other vascular manifestations such as microangiopathy, chronic arteriopathy and catastrophic APS (CAPS). Certain laboratory tests for the syndrome (for example, the lupus anticoagulant test) can be affected by the use of anticoagulant agents, making diagnosis more difficult. The pathophysiology of APS is complex, and several mechanisms of pathogenesis related to coagulation, endothelium, and platelets are discussed in this article. We conclude by discussing treatment of APS according to the presence and type of clinical manifestations, use of direct oral anticoagulants (DOAs), and perioperative management of patients with APS.

A síndrome antifosfolipíde (SAF) é uma doença autoimune sistêmica caracterizada por trombose arterial ou venosa recorrente e/ou morbidade gestacional e pela presença dos anticorpos antifosfolipídeos, podendo apresentar outras manifestações vasculares, como microangiopatia, arteriopatia crônica e SAF catastrófica. Determinados testes laboratoriais para a síndrome (por exemplo, o anticoagulante lúpico) podem sofrer interferência do uso de medicações anticoagulantes, dificultando o diagnóstico. A fisiopatologia da SAF é complexa, sendo enumerados no texto diversos mecanismos patogênicos relacionados à coagulação, ao endotélio e às plaquetas. Por fim, discutimos o tratamento da SAF de acordo com a presença e o tipo de manifestações clínicas, o uso dos anticoagulantes orais diretos e o manejo perioperatório de pacientes com SAF.

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Conflict of interest statement

Conflito de interesse: Os autores declararam não haver conflitos de interesse que precisam ser informados.

References

    1. Merashli M, Noureldine MHA, Uthman I, Khamashta M. Antiphospholipid syndrome: an update. Eur J Clin Invest. 2015;45(6):653–662. http://dx.doi.org/10.1111/eci.12449 - DOI - PubMed
    1. Gómez-Puerta JA, Cervera R. Diagnosis and classification of the antiphospholipid syndrome. J Autoimmun. 2014;48-49:20–25. http://dx.doi.org/10.1016/j.jaut.2014.01.006 - DOI - PubMed
    1. Pons-Estel GJ, Cervera R. Renal involvement in antiphospholipid syndrome. Curr Rheumatol Rep. 2014;16(2):397. http://dx.doi.org/10.1007/s11926-013-0397-0 - DOI - PubMed
    1. Christodoulou C, Sangle S, D’Cruz DP. Vasculopathy and arterial stenotic lesions in the antiphospholipid syndrome. Rheumatology. 2007;46(6):907–910. http://dx.doi.org/10.1093/rheumatology/kem040 - DOI - PubMed
    1. Belizna CC, Richard V, Primard E, et al. Early atheroma in primary and secondary antiphospholipid syndrome: an intrinsic finding. Semin Arthritis Rheum. 2008;37(6):373–380. http://dx.doi.org/10.1016/j.semarthrit.2007.08.002 - DOI - PubMed

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