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Review
. 2019 Jul;68(3):420-426.
doi: 10.1007/s12031-018-1087-1. Epub 2018 Jun 22.

Effects of PACAP on Dry Eye Symptoms, and Possible Use for Therapeutic Application

Seiji Shioda  1 , Fumiko Takenoya  2 , Takahiro Hirabayashi  2 , Nobuhiro Wada  2 , Tamotsu Seki  3 , Naoko Nonaka  4 , Tomoya Nakamachi  5
Affiliations
Review

Effects of PACAP on Dry Eye Symptoms, and Possible Use for Therapeutic Application

Seiji Shioda et al. J Mol Neurosci. 2019 Jul.

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family of peptides. PACAP and its three receptor subtypes are expressed in neural tissues and in the eye, including the retina, cornea, and lacrimal gland. PACAP is known to exert pleiotropic effects on the central nervous system and in eye tissues where it plays important roles in protecting against dry eye. This review provides an overview of current knowledge regarding dry eye symptoms in aged animals and humans and the protective effects, mechanisms of action. In addition, we also refer to the development of a new preventive/therapeutic method by PACAP of dry eye patients.

Keywords: Aging; Dry eye; Neuroprotective function; PACAP.

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