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Review
. 2018 Oct;34(7):e3042.
doi: 10.1002/dmrr.3042. Epub 2018 Jul 17.

Obesity and diabetes-Not only a simple link between two epidemics

Agata Chobot  1 , Katarzyna Górowska-Kowolik  1 , Magdalena Sokołowska  2 , Przemysława Jarosz-Chobot  3
Affiliations
Review

Obesity and diabetes-Not only a simple link between two epidemics

Agata Chobot et al. Diabetes Metab Res Rev. 2018 Oct.

Abstract

Diabetes (DM) as well as obesity, due to their increasing incidence, were recognized as epidemic by the World Health Organization. Obesity is involved not only in the aetiopathogenesis of the most common worldwide type of DM-type 2 diabetes-but also in the development of its complications. There is also increasing scientific evidence regarding the role of obesity and overweight in type 1 diabetes. Weight gain may be considered as a complication of insulin treatment but also reveals significant pathophysiological impact on various stages of the disease. Another very important aspect related to DM as well as obesity is the microbiome, which is highly variable. The function of the gut microflora, its interaction with the whole organism, and its role in the development of obesity and type 1 diabetes as well as type 2 diabetes are still not fully understood and subject of ongoing investigations. This review presents a summary of recently published results concerning the relation of obesity/overweight and DM as well as their associations with the microbiome.

Keywords: diabetes; epidemiology; insulin resistance; microbiome; obesity; type 1 diabetes; type 2 diabetes.

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Figure 1
Figure 1
Possible mechanisms involved in the relation between microbiome diabetes and obesity. T1D, type 1 diabetes; T2D, type 2 diabetes
See this image and copyright information in PMC

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