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. 2018 Jul 26;57(31):9896-9900.
doi: 10.1002/anie.201802466. Epub 2018 Jul 13.

Hypervalent Iodine(III)-Catalyzed Balz-Schiemann Fluorination under Mild Conditions

Bo Xing  1 , Chuanfa Ni  1 , Jinbo Hu  1
Affiliations

Hypervalent Iodine(III)-Catalyzed Balz-Schiemann Fluorination under Mild Conditions

Bo Xing et al. Angew Chem Int Ed Engl. .

Abstract

An unprecedented hypervalent iodine(III) catalyzed Balz-Schiemann reaction is described. In the presence of a hypervalent iodine compound, the fluorination reaction proceeds under mild conditions (25-60 °C), and features a wide substrate scope and good functional-group compatibility.

Keywords: Balz-Schiemann reaction; aryl fluorides; diazonium salts; fluorination; iodine.

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