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doi: 10.1016/j.molcel.2018.06.009.
Tailing Off: PABP and CNOT Generate Cycles of mRNA Deadenylation
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- PMID: 29932908
- DOI: 10.1016/j.molcel.2018.06.009
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Tailing Off: PABP and CNOT Generate Cycles of mRNA Deadenylation
Mol Cell.
.
Free article
Abstract
In this issue of Molecular Cell, Webster et al. (2018) and Yi et al. (2018) dissect the mechanisms underlying cytoplasmic mRNA deadenylation by the Ccr4-Not (CNOT) complex. Crucial to this process is the poly(A) binding protein Pab1/PABPC1, which both stimulates and suppresses the activity of different deadenylases.
Copyright © 2018 Elsevier Inc. All rights reserved.
Comment on
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PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay.Mol Cell. 2018 Jun 21;70(6):1081-1088.e5. doi: 10.1016/j.molcel.2018.05.009. Mol Cell. 2018. PMID: 29932901
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mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases.Mol Cell. 2018 Jun 21;70(6):1089-1100.e8. doi: 10.1016/j.molcel.2018.05.033. Mol Cell. 2018. PMID: 29932902 Free PMC article.
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