Meditation or exercise for preventing acute respiratory infection (MEPARI-2): A randomized controlled trial

Abstract

Background: Practice of meditation or exercise may enhance health to protect against acute infectious illness.

Objective: To assess preventive effects of meditation and exercise on acute respiratory infection (ARI) illness.

Design: Randomized controlled prevention trial with three parallel groups.

Setting: Madison, Wisconsin, USA.

Participants: Community-recruited adults who did not regularly exercise or meditate.

Methods: 1) 8-week behavioral training in mindfulness-based stress reduction (MBSR); 2) matched 8-week training in moderate intensity sustained exercise (EX); or 3) observational waitlist control. Training classes occurred in September and October, with weekly ARI surveillance through May. Incidence, duration, and area-under-curve ARI global severity were measured using daily reports on the WURSS-24 during ARI illness. Viruses were identified multiplex PCR. Absenteeism, health care utilization, and psychosocial health self-report assessments were also employed.

Results: Of 413 participants randomized, 390 completed the trial. In the MBSR group, 74 experienced 112 ARI episodes with 1045 days of ARI illness. Among exercisers, 84 had 120 episodes totaling 1010 illness days. Eighty-two of the controls had 134 episodes with 1210 days of ARI illness. Mean global severity was 315 for MBSR (95% confidence interval 244, 386), 256 (193, 318) for EX, and 336 (268, 403) for controls. A prespecified multivariate zero-inflated regression model suggested reduced incidence for MBSR (p = 0.036) and lower global severity for EX (p = 0.042), compared to control, not quite attaining the p<0.025 prespecified cut-off for null hypothesis rejection. There were 73 ARI-related missed-work days and 22 ARI-related health care visits in the MBSR group, 82 days and 21 visits for exercisers, and 105 days and 24 visits among controls. Viruses were identified in 63 ARI episodes in the MBSR group, compared to 64 for EX and 72 for control. Statistically significant (p<0.05) improvements in general mental health, self-efficacy, mindful attention, sleep quality, perceived stress, and depressive symptoms were observed in the MBSR and/or EX groups, compared to control.

Conclusions: Training in mindfulness meditation or exercise may help protect against ARI illness.

Limitations: This trial was likely underpowered.

Trial registration: Clinicaltrials.gov NCT01654289.

Fig 1. Primary intention-to-treat efficacy analyses includes all participants (n = 413).

Fig 2. ARI = acute respiratory infection; Global severity = Area under time severity curve, calculated as trapezoidal approximation using daily scores on Wisconsin Upper Respiratory Infection Symptom Severity (WURSS-24) for y-axis and duration of ARI illness as x-axis; Error lines indicate 95% confidence intervals.