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Comment
. 2018 Jul;41(7):413-414.
doi: 10.1016/j.tins.2018.04.001.

Linking the Gut Microbiota to a Brain Neurotransmitter

Kelly G Jameson  1 , Elaine Y Hsiao  2
Affiliations
Comment

Linking the Gut Microbiota to a Brain Neurotransmitter

Kelly G Jameson et al. Trends Neurosci. 2018 Jul.

Abstract

The past decade has yielded substantial evidence that the gut microbiome modulates brain function, including for instance behaviors relevant to anxiety and depression, pointing to a need to identify the biological pathways involved. In 2013 Clarke and colleagues reported that the early-life microbiome regulates the hippocampal serotonergic system in a sex-dependent manner, findings that opened up numerous lines of inquiry on the effects of the microbiome on neurodevelopment and behavior.

Keywords: anxiety; gut–brain axis; microbiome; microbiota; serotonin; stress.

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References

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