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. 2018 Oct;142(4):1360-1363.e3.
doi: 10.1016/j.jaci.2018.05.037. Epub 2018 Jun 21.

Eosinophil-degranulation products drive a proinflammatory fibroblast phenotype

Ksenija Bernau  1 , Jonathan P Leet  1 , Stephane Esnault  1 , Andrea L Noll  1 , Michael D Evans  2 , Nizar N Jarjour  1 , Nathan Sandbo  3
Affiliations

Eosinophil-degranulation products drive a proinflammatory fibroblast phenotype

Ksenija Bernau et al. J Allergy Clin Immunol. 2018 Oct.
No abstract available

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Conflict of interest statement

The authors have no financial or other conflicts of interest with this publication to disclose.

Figures

Figure 1
Figure 1. HBF stimulated by IL3-HAIgG-activated eosinophils express chemokines important for neutrophil migration
HBF stimulated with IL3-HAIgG ES, IL3 ES, rhIL3-HAIgG, or growth medium for 24h (A–D) or 72h (E, F). mRNA levels of CXCL8 (A), IL6 (B), CXCL1 (C) and ICAM1 (D) in HBF. IL8 (E) and IL6 (F) ELISA of supernatant from HBF or from IL3-HAIgG ES alone.
Figure 2
Figure 2. Supernatants from IL3-HAIgG ES-stimulated HBF induce increased neutrophil chemotaxis
(A) Transwell neutrophil migration in response to indicated HBF supernatants, IL3-HAIgG ES, 30 ng/ml IL8, or growth medium. (B) Correlation of transwell neutrophil migration to IL8 content in IL3-HAIgG ES- stimulated HBF supernatants.
See this image and copyright information in PMC

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