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. 2018 Aug 15:1092:328-331.
doi: 10.1016/j.jchromb.2018.06.022. Epub 2018 Jun 13.

A new cause of false positive voriconazole levels: Watch your collection tubes!

Almudena Burillo  1 , Alicia Gómez-López  2 , Pilar Escribano  3 , Alicia Galar  3 , Beatriz Salinas  4 , Nadire Díaz-Pérez  5 , Patricia Muñoz  6 , Emilio Bouza  7
Affiliations

A new cause of false positive voriconazole levels: Watch your collection tubes!

Almudena Burillo et al. J Chromatogr B Analyt Technol Biomed Life Sci. .

Abstract

We communicate the interference of a compound of the blood collection tube with the accuracy of a validated high-pressure liquid chromatography method with ultraviolet detection for quantifying voriconazole levels, which led to false positive results. This could have serious consequences for patient management. Our advice is to implement external assessment programs.

Keywords: Chromatography; Clinical laboratory techniques; Data accuracy; High-pressure liquid; Therapeutic drug monitoring; Voriconazole.

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