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. 2018 May-Jun;63(3):261-263.
doi: 10.4103/ijd.IJD_69_18.

Reed's Syndrome

Filipa Tavares Almeida  1 , Rui P Santos  1 , Sofia D Carvalho  2 , Maria C Brito  1
Affiliations

Reed's Syndrome

Filipa Tavares Almeida et al. Indian J Dermatol. 2018 May-Jun.

Abstract

Multiple cutaneous and uterine leiomyomatosis (MCUL), also known as Reed's syndrome, is a rare genodermatosis, with an autosomal dominant pattern of inheritance. It results from a germline heterozygous mutation of fumarate hydratase gene, that is classified as a tumor suppressor gene. Hereditary leiomyomatosis and renal cell cancer is characterized by the association of MCUL with renal cell carcinoma. We report a case of a 57-year-old woman, with multiple cutaneous leiomyomas as the presenting sign of Reed's syndrome.

Keywords: Fumarate hydratase; leiomyomatosis; renal cell cancer.

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Conflict of interest statement

There are no conflicts of interest. What is new? Patients with Reed1s syndrome may be predisposed to develop renal cysts.

Figures

Figure 1
Figure 1
Cutaneous leiomyomas grouped in the upper back
Figure 2
Figure 2
Cutaneous leiomyoma (H and E, ×100)
Figure 3
Figure 3
Cytoplasmic expression of smooth muscle actin (Immunohistochemistry, ×100)
See this image and copyright information in PMC

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