Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jun 25;18(8):53.
doi: 10.1007/s11910-018-0855-1.

Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia

Affiliations
Review

Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia

Antonio Culebras et al. Curr Neurol Neurosci Rep. .

Abstract

Purpose of review: In this article, we review the cerebrovascular complications of sleep apnea (SA). SA is the major sleep disorder associated with stroke and vascular dementia.

Recent findings: Sleep apnea syndrome of moderate to severe intensity affects 17% of 50-70-year-old men and 9% of 50-70-year-old women, making SA a notorious and prevalent disorder. SA increases the risk of hypertension, stroke, myocardial infarction, and atrial fibrillation (AF) and is closely linked to vascular dementia. In addition, SA may worsen the neurologic outcome in acute stroke patients and interferes with rehabilitation after stroke. Proper management of SA may decrease the clinical impact of stroke risk factors, improve neurologic outcome after stroke, and lessen the progression of subcortical ischemic vascular disease. In this article, we will cover the most salient pathologies that associate SA and cerebrovascular pathology.

Keywords: Atrial fibrillation; CPAP; Hypertension; Sleep apnea; Stroke; Vascular dementia; White matter hyperintensities.

PubMed Disclaimer

Similar articles

Cited by

  • International Consensus Statement on Obstructive Sleep Apnea.
    Chang JL, Goldberg AN, Alt JA, Mohammed A, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera JE, Bartley BL, Billings ME, Boon MS, Bosschieter P, Braverman I, Brodie K, Cabrera-Muffly C, Caesar R, Cahali MB, Cai Y, Cao M, Capasso R, Caples SM, Chahine LM, Chang CP, Chang KW, Chaudhary N, Cheong CSJ, Chowdhuri S, Cistulli PA, Claman D, Collen J, Coughlin KC, Creamer J, Davis EM, Dupuy-McCauley KL, Durr ML, Dutt M, Ali ME, Elkassabany NM, Epstein LJ, Fiala JA, Freedman N, Gill K, Gillespie MB, Golisch L, Gooneratne N, Gottlieb DJ, Green KK, Gulati A, Gurubhagavatula I, Hayward N, Hoff PT, Hoffmann OMG, Holfinger SJ, Hsia J, Huntley C, Huoh KC, Huyett P, Inala S, Ishman SL, Jella TK, Jobanputra AM, Johnson AP, Junna MR, Kado JT, Kaffenberger TM, Kapur VK, Kezirian EJ, Khan M, Kirsch DB, Kominsky A, Kryger M, Krystal AD, Kushida CA, Kuzniar TJ, Lam DJ, Lettieri CJ, Lim DC, Lin HC, Liu SYC, MacKay SG, Magalang UJ, Malhotra A, Mansukhani MP, Maurer JT, May AM, Mitchell RB, Mokhlesi B, Mullins AE, Nada EM, Naik S, Nokes B, Olson MD, Pack AI, Pang EB, Pang KP, Patil SP, Van de Perck E, Piccirillo JF, Pien GW, Piper AJ, Plawecki A, Quigg M, Ravesloot MJL, Redline S, Rotenberg BW, Ryden … See abstract for full author list ➔ Chang JL, et al. Int Forum Allergy Rhinol. 2023 Jul;13(7):1061-1482. doi: 10.1002/alr.23079. Epub 2023 Mar 30. Int Forum Allergy Rhinol. 2023. PMID: 36068685 Free PMC article. Review.
  • Cardiorespiratory Fitness Attenuates the Deleterious Effects of Sleep Apnea on Cerebral Structure and Perfusion in the Wisconsin Sleep Cohort Study.
    Edmunds KJ, Driscoll I, Hagen EW, Barnet JH, Ravelo LA, Plante DT, Gaitán JM, Lose SR, Motovylyak A, Bendlin BB, Okonkwo OC, Peppard PE. Edmunds KJ, et al. J Alzheimers Dis. 2023;95(2):427-435. doi: 10.3233/JAD-220910. J Alzheimers Dis. 2023. PMID: 37545229 Free PMC article.
  • Neurological impairments in Duchenne muscular dystrophy: A comprehensive review.
    Zhang XF, Hu W, Hu J. Zhang XF, et al. Acta Neurol Belg. 2025 Sep 4. doi: 10.1007/s13760-025-02880-2. Online ahead of print. Acta Neurol Belg. 2025. PMID: 40903659 Review.
  • Interplay Between Vascular Dysfunction and Neurodegenerative Pathology: New Insights into Molecular Mechanisms and Management.
    Mekala A, Qiu H. Mekala A, et al. Biomolecules. 2025 May 13;15(5):712. doi: 10.3390/biom15050712. Biomolecules. 2025. PMID: 40427605 Free PMC article. Review.
  • Impact of Intermittent Hypoxia on Sepsis Outcomes in a Murine Model.
    Chou KT, Cheng SC, Huang SF, Perng DW, Chang SC, Chen YM, Hsu HS, Hung SC. Chou KT, et al. Sci Rep. 2019 Sep 9;9(1):12900. doi: 10.1038/s41598-019-49381-w. Sci Rep. 2019. PMID: 31501504 Free PMC article.

References

    1. Lancet Neurol. 2004 Jun;3(6):333-42 - PubMed
    1. J Hypertens. 2001 Dec;19(12):2271-7 - PubMed
    1. Circulation. 2003 May 27;107(20):2589-94 - PubMed
    1. Am J Respir Crit Care Med. 2010 Jul 15;182(2):269-77 - PubMed
    1. J Am Coll Cardiol. 2007 Feb 6;49(5):565-71 - PubMed

MeSH terms

LinkOut - more resources