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. 1985 Jun;5(6):1534-7.
doi: 10.1128/mcb.5.6.1534-1537.1985.

Host species specificity of polyomavirus DNA replication is not altered by simian virus 40 72-base-pair repeats

B A Campbell, L P Villarreal

Host species specificity of polyomavirus DNA replication is not altered by simian virus 40 72-base-pair repeats

B A Campbell et al. Mol Cell Biol. 1985 Jun.

Abstract

The simian virus 40 72-base-pair repeats substituted for the polyomavirus enhancer, allowing replication and transcription in mouse 3T6 but not monkey CV-1 cells. A polyomavirus genome containing the entire simian virus 40 control region replicated at low levels in 3T6 and CV-1 cells; however, transcripts were detected only in 3T6 cells. Our results suggest that the simian virus 40 72-base-pair repeats are unable to alter the host species specificity of the complete polyomavirus genome.

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