Induction of sister-chromatid exchanges by restriction endonucleases
- PMID: 2993874
- DOI: 10.1016/0165-7992(85)90121-6
Induction of sister-chromatid exchanges by restriction endonucleases
Abstract
Restriction endonucleases Cfo 1, Pvu II, Sma I, Hpa II, Taq I and Hae III were tested for their ability to induce SCEs in CHO cells. The results indicate that the DNA double-strand breaks induced during S-phase by these enzymes lead to an increase in the frequencies of SCEs.
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