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Comparative Study
. 1985 Sep;144(1):33-9.
doi: 10.1016/0165-7992(85)90121-6.

Induction of sister-chromatid exchanges by restriction endonucleases

A T Natarajan, L H Mullenders, M Meijers, U Mukherjee
Comparative Study

Induction of sister-chromatid exchanges by restriction endonucleases

A T Natarajan et al. Mutat Res. 1985 Sep.

Abstract

Restriction endonucleases Cfo 1, Pvu II, Sma I, Hpa II, Taq I and Hae III were tested for their ability to induce SCEs in CHO cells. The results indicate that the DNA double-strand breaks induced during S-phase by these enzymes lead to an increase in the frequencies of SCEs.

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