Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Sep 20;24(53):14054-14058.
doi: 10.1002/chem.201802907. Epub 2018 Aug 27.

Brønsted Base Assisted Photoredox Catalysis: Proton Coupled Electron Transfer for Remote C-C Bond Formation via Amidyl Radicals

Jiaqi Jia  1 , Yee Ann Ho  1 , Raoul F Bülow  1 , Magnus Rueping  1   2
Affiliations

Brønsted Base Assisted Photoredox Catalysis: Proton Coupled Electron Transfer for Remote C-C Bond Formation via Amidyl Radicals

Jiaqi Jia et al. Chemistry. .

Abstract

The synthesis of alkyne- and alkene-decorated lactams has been achieved through a photoredox-initiated radical cascade reaction. The developed Brønsted base assisted, photoredox-catalyzed, intramolecular 5-exo-trig cyclization/intermolecular radical addition/elimination reaction provides facile access to functionalized γ-lactams, with good functional group tolerance and high yields.

Keywords: Brønsted base; lactam derivatives; photoredox catalysis; proton-coupled electron transfer (PCET); radical reactions; sulfonyl radical.

PubMed Disclaimer

LinkOut - more resources