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Book

Progeria

Christine K. Sickles  1 , Gary P. Gross  1
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Progeria

Christine K. Sickles et al.
Free Books & Documents

Excerpt

Werner syndrome (WS) is 1 of the premature aging syndromes named progeria. Otto Werner first described it in 1904. It is a rare autosomal recessive condition that begins in late adolescence or early adulthood. It presents with characteristic physical and metabolic abnormalities that result in severe age-associated complications, such as diabetes, hypertension, osteoporosis, myocardial infarction, stroke, and cancer, that are normally seen in the elderly population.

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Conflict of interest statement

Disclosure: Christine Sickles declares no relevant financial relationships with ineligible companies.

Disclosure: Gary Gross declares no relevant financial relationships with ineligible companies.

References

    1. Sarbacher CA, Halper JT. Connective Tissue and Age-Related Diseases. Subcell Biochem. 2019;91:281-310. - PubMed
    1. Isaev NK, Stelmashook EV, Genrikhs EE. Neurogenesis and brain aging. Rev Neurosci. 2019 Jul 26;30(6):573-580. - PubMed
    1. Kuk MU, Kim JW, Lee YS, Cho KA, Park JT, Park SC. Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models. Mol Cells. 2019 Mar 31;42(3):210-217. - PMC - PubMed
    1. Sargolzaeiaval F, Zhang J, Schleit J, Lessel D, Kubisch C, Precioso DR, Sillence D, Hisama FM, Dorschner M, Martin GM, Oshima J. CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures. Mol Genet Genomic Med. 2018 Nov;6(6):1148-1156. - PMC - PubMed
    1. Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L, Ju Z, Chan P, Song M, Qu J, Liu GH. Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell. 2019 Jun;10(6):417-435. - PMC - PubMed

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