Troponin
- PMID: 29939582
- Bookshelf ID: NBK507805
Troponin
Excerpt
Diagnosing cardiac emergencies is one of the most crucial tasks delegated to the emergency provider. The broad differential diagnosis of chest pain must be narrowed down quickly and accurately to perform the life-saving treatments patients require. Along with the history and physical examination, several important diagnostic tools are used to differentiate the different causes of chest pain. One tool that has become an essential component of cardiac workups and diagnosis is the measurement of troponins.
Cardiac troponins have been available for clinical use since 1995, when the first cardiac troponin T (cTnT) assay was approved. Since then, it has become clear that enhanced cardiac specificity and particularly improved sensitivity lead to more frequent and more accurate diagnoses of cardiovascular abnormalities, especially with the implementation of high-sensitivity cardiac troponins assays.
Copyright © 2025, StatPearls Publishing LLC.
Conflict of interest statement
Sections
- Introduction
- Etiology and Epidemiology
- Pathophysiology
- Specimen Requirements and Procedure
- Diagnostic Tests
- Testing Procedures
- Interfering Factors
- Results, Reporting, and Critical Findings
- Clinical Significance
- Quality Control and Lab Safety
- Enhancing Healthcare Team Outcomes
- Review Questions
- References
References
-
- Aakre KM, Omland T. Physical activity, exercise and cardiac troponins: Clinical implications. Prog Cardiovasc Dis. 2019 Mar-Apr;62(2):108-115. - PubMed
-
- Mirkin J, Radecki R, Spiegel R. Deriving Peace of Mind: In Search of a Fifth-Generation Troponin Testing Threshold to Safely Rule Out Acute Myocardial Infarction: March 2019 Annals of Emergency Medicine Journal Club. Ann Emerg Med. 2019 Mar;73(3):317-319. - PubMed
-
- Potocki M, Reichlin T, Thalmann S, Zellweger C, Twerenbold R, Reiter M, Steuer S, Bassetti S, Drexler B, Stelzig C, Freese M, Winkler K, Haaf P, Balmelli C, Hochholzer W, Osswald S, Mueller C. Diagnostic and prognostic impact of copeptin and high-sensitivity cardiac troponin T in patients with pre-existing coronary artery disease and suspected acute myocardial infarction. Heart. 2012 Apr;98(7):558-65. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Research Materials