Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Dextroamphetamine-Amphetamine

Preeti Patel, Raman Marwaha  1 , Mohammed Molla  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Dextroamphetamine-Amphetamine

Preeti Patel et al.
Free Books & Documents

Excerpt

The dextroamphetamine-amphetamine combination is a central nervous system stimulant classified as a Schedule II drug by the Drug Enforcement Administration (DEA) and the US Food and Drug Administration (FDA) due to its high potential for abuse. Both immediate-release and sustained-release amphetamine medications are FDA-approved for treating attention-deficit hyperactivity disorder (ADHD) and narcolepsy in adult and pediatric populations. The drug works by increasing dopamine and norepinephrine levels through catecholamine release and reuptake inhibition. Off-label uses of dextroamphetamine-amphetamine include the management of cerebrovascular accidents.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Preeti Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Raman Marwaha declares no relevant financial relationships with ineligible companies.

Disclosure: Mohammed Molla declares no relevant financial relationships with ineligible companies.

References

    1. Chen LY, Crum RM, Strain EC, Alexander GC, Kaufmann C, Mojtabai R. Prescriptions, nonmedical use, and emergency department visits involving prescription stimulants. J Clin Psychiatry. 2016 Mar;77(3):e297-304. - PMC - PubMed
    1. Lakhan SE, Kirchgessner A. Prescription stimulants in individuals with and without attention deficit hyperactivity disorder: misuse, cognitive impact, and adverse effects. Brain Behav. 2012 Sep;2(5):661-77. - PMC - PubMed
    1. Maski K, Trotti LM, Kotagal S, Robert Auger R, Rowley JA, Hashmi SD, Watson NF. Treatment of central disorders of hypersomnolence: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2021 Sep 01;17(9):1881-1893. - PMC - PubMed
    1. Walker-Batson D, Smith P, Curtis S, Unwin H, Greenlee R. Amphetamine paired with physical therapy accelerates motor recovery after stroke. Further evidence. Stroke. 1995 Dec;26(12):2254-9. - PubMed
    1. Sommer CJ, Schäbitz WR. Principles and requirements for stroke recovery science. J Cereb Blood Flow Metab. 2021 Mar;41(3):471-485. - PMC - PubMed

Publication types

LinkOut - more resources