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Cryptogenic organizing pneumonia (COP), formerly bronchiolitis obliterans organizing pneumonia (BOOP), is a form of idiopathic diffuse interstitial lung disease. Davison et al coined the term COP in 1983, which was followed by detailed descriptions of the disease under the term BOOP by Epler et al in 1985. Cryptogenic organizing pneumonia is believed to be a consequence of alveolar injury. This condition is characterized by the formation of organized buds of granulation tissue obstructing the alveolar lumen and bronchioles, resulting in respiratory failure. Organizing pneumonia is a pathologic diagnosis and can be secondary to an identifiable etiology. Cryptogenic organizing pneumonia should be diagnosed only after excluding any other possible etiology.
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Shen L, Liu J, Huang L, Zhang Y, Xiao X, Yu H. Cryptogenic Organizing Pneumonia Presenting as a Solitary Mass: Clinical, Imaging, and Pathologic Features. Med Sci Monit. 2019 Jan 16;25:466-474.
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Saito Z, Kaneko Y, Hasegawa T, Yoshida M, Odashima K, Horikiri T, Kinoshita A, Saitoh K, Kuwano K. Predictive factors for relapse of cryptogenic organizing pneumonia. BMC Pulm Med. 2019 Jan 09;19(1):10.
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Wieruszewski PM, Herasevich S, Gajic O, Yadav H. Respiratory failure in the hematopoietic stem cell transplant recipient. World J Crit Care Med. 2018 Oct 16;7(5):62-72.
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