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Book

Acute Myeloid Leukemia

Anusha Vakiti, Samuel B. Reynolds  1 , Prerna Mewawalla  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Acute Myeloid Leukemia

Anusha Vakiti et al.
Free Books & Documents

Excerpt

Acute myeloid leukemia (AML) is a rapidly progressing myeloid neoplasm characterized by the clonal expansion of immature myeloid-derived cells, known as blasts, in the peripheral blood and bone marrow. This expansion results in ineffective erythropoiesis and megakaryopoiesis, clinically manifesting as relatively rapid bone marrow failure compared to chronic and indolent leukemias. This leads to inadequate production of red blood cells and platelets.

Although the administration of multiagent induction chemotherapy can induce complete remission, allogeneic stem cell transplantation is the only established curative therapy. Despite advancements in therapeutic approaches, prognosis remains suboptimal, especially among the older populations..

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Conflict of interest statement

Disclosure: Anusha Vakiti declares no relevant financial relationships with ineligible companies.

Disclosure: Samuel Reynolds declares no relevant financial relationships with ineligible companies.

Disclosure: Prerna Mewawalla declares no relevant financial relationships with ineligible companies.

References

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    1. Medeiros BC, Chan SM, Daver NG, Jonas BA, Pollyea DA. Optimizing survival outcomes with post-remission therapy in acute myeloid leukemia. Am J Hematol. 2019 Jul;94(7):803-811. - PMC - PubMed
    1. Hartmann L, Metzeler KH. Clonal hematopoiesis and preleukemia-Genetics, biology, and clinical implications. Genes Chromosomes Cancer. 2019 Dec;58(12):828-838. - PubMed
    1. Boddu PC, Zeidan AM. Myeloid disorders after autoimmune disease. Best Pract Res Clin Haematol. 2019 Mar;32(1):74-88. - PMC - PubMed

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