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. 1985 Sep;82(17):5751-5.
doi: 10.1073/pnas.82.17.5751.

beta-Endorphin: surface binding and internalization in thymoma cells

L Schweigerer, W Schmidt, H Teschemacher, C Gramsch

beta-Endorphin: surface binding and internalization in thymoma cells

L Schweigerer et al. Proc Natl Acad Sci U S A. 1985 Sep.

Abstract

The opioid peptide beta-endorphin binds to specific nonopioid binding sites (Mr 72,000) that are present on the surface of thymoma cells. beta-Endorphin is then internalized, apparently via the Mr 72,000 species, and is subsequently found within intracellular, vesicular structures. This process is accompanied by the down-regulation of the Mr 72,000 binding sites. Our findings suggest that beta-endorphin may modulate cellular functions, such as T-lymphocyte proliferation, at intracellular rather than cell surface sites.

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References

    1. J Cell Biol. 1976 Oct;71(1):159-71 - PubMed
    1. Nature. 1984 Dec 20-1985 Jan 2;312(5996):716-20 - PubMed
    1. Annu Rev Biochem. 1977;46:669-722 - PubMed
    1. J Biol Chem. 1979 Mar 25;254(6):1765-7 - PubMed
    1. Nature. 1979 Jun 21;279(5715):679-85 - PubMed

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