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Comparative Study
. 1985 Sep;82(17):5800-4.
doi: 10.1073/pnas.82.17.5800.

Comparative statistics for DNA and protein sequences: single sequence analysis

S Karlin, G Ghandour
Comparative Study

Comparative statistics for DNA and protein sequences: single sequence analysis

S Karlin et al. Proc Natl Acad Sci U S A. 1985 Sep.

Abstract

Four categories of data representations are used to help interpret structures and similarities of nucleic acid and protein sequences. Statistical significance of the observed relationships revealed by these representations are assessed by a hierarchy of permutation procedures and by comparisons with theoretical random models. Applications are presented for various DNA sequences including papovaviruses, Epstein-Barr virus, mitochondrial genomes, and several globin and immunoglobulin genes.

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