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. 1985 Sep;82(17):5944-8.
doi: 10.1073/pnas.82.17.5944.

A third viral nuclear protein in lymphoblasts immortalized by Epstein-Barr virus

K Hennessy, S Fennewald, E Kieff

A third viral nuclear protein in lymphoblasts immortalized by Epstein-Barr virus

K Hennessy et al. Proc Natl Acad Sci U S A. 1985 Sep.

Abstract

Most sera from patients with rheumatoid arthritis as well as some sera from normal Epstein-Barr virus (EBV)-infected people detect a 140-kDa protein on immunoblots of EBV-infected lymphoblasts. The 140-kDa protein is a nuclear protein characteristic of latent EBV infection. Sera reactive with this protein identify a distinctive globular nuclear antigen. Although the 140-kDa protein is encoded by EBV, it is not encoded by genes that encode the two previously described EBV nuclear antigens (EBNA) or the latent-infection membrane protein. The 140-kDa protein is therefore designated EBNA3. The EBV genes, including the gene encoding EBNA3, that are characteristically expressed in latent infection are likely to play a role in the maintenance of persistent latent viral infection or in the cell proliferation caused by virus infection.

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