Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle
- PMID: 2994073
- PMCID: PMC391052
- DOI: 10.1073/pnas.82.18.6352
Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle
Abstract
The role of inositol 1,4,5-trisphosphate (InsP3) in excitation-contraction coupling in skeletal muscle was investigated by several methods. The following results were obtained. InsP3 is released by electrical stimulation of muscles. Exogenous InsP3 releases calcium from skinned muscle fibers at relatively high doses under normal conditions but does so at very low concentrations when blockers of the InsP3 5-phosphatase are present. Blockers of InsP3 release are effective blockers of calcium transients elicited by electrical stimulation of muscle fibers. It is proposed that InsP3 acts as a chemical second messenger between transverse (T)-tubular membrane depolarization and calcium release from the sarcoplasmic reticulum in skeletal muscle.
Similar articles
-
Inositol trisphosphate and excitation-contraction coupling in skeletal muscle.J Bioenerg Biomembr. 1989 Apr;21(2):267-81. doi: 10.1007/BF00812072. J Bioenerg Biomembr. 1989. PMID: 2546932 Review.
-
Role of inositol 1,4,5-trisphosphate in excitation-contraction coupling in skeletal muscle.FEBS Lett. 1986 Mar 3;197(1-2):1-4. doi: 10.1016/0014-5793(86)80285-x. FEBS Lett. 1986. PMID: 2419159 Review.
-
Voltage dependence of inositol 1,4,5-trisphosphate-induced Ca2+ release in peeled skeletal muscle fibers.Proc Natl Acad Sci U S A. 1988 Aug;85(15):5749-53. doi: 10.1073/pnas.85.15.5749. Proc Natl Acad Sci U S A. 1988. PMID: 3261014 Free PMC article.
-
An examination of the ability of inositol 1,4,5-trisphosphate to induce calcium release and tension development in skinned skeletal muscle fibres of frog and crustacea.FEBS Lett. 1986 Oct 20;207(1):153-61. doi: 10.1016/0014-5793(86)80031-x. FEBS Lett. 1986. PMID: 3490400
-
Opening of dihydropyridine calcium channels in skeletal muscle membranes by inositol trisphosphate.Nature. 1988 Dec 8;336(6199):587-9. doi: 10.1038/336587a0. Nature. 1988. PMID: 2462164
Cited by
-
Chemical transmission at the triad: InsP3?J Muscle Res Cell Motil. 1991 Aug;12(4):316-20. doi: 10.1007/BF01738586. J Muscle Res Cell Motil. 1991. PMID: 1658039 No abstract available.
-
A concentration-dependent localization of octopamine-sensitive adenylate cyclase activity in locust skeletal muscle.Histochemistry. 1989;92(3):255-60. doi: 10.1007/BF00500926. Histochemistry. 1989. PMID: 2506154
-
Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor.Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2941-4. doi: 10.1073/pnas.0536227100. Epub 2003 Feb 24. Proc Natl Acad Sci U S A. 2003. PMID: 12601149 Free PMC article.
-
Properties of calcium currents and contraction in cultured rat diaphragm muscle.Pflugers Arch. 1995 Sep;430(5):837-45. doi: 10.1007/BF00386184. Pflugers Arch. 1995. PMID: 7478941
-
Single channel measurements of the calcium release channel from skeletal muscle sarcoplasmic reticulum. Activation by Ca2+ and ATP and modulation by Mg2+.J Gen Physiol. 1986 Nov;88(5):573-88. doi: 10.1085/jgp.88.5.573. J Gen Physiol. 1986. PMID: 2431098 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
