Review

. 2018:139:35-56.

doi: 10.1016/bs.acr.2018.05.003. Epub 2018 Jun 7.

Nanotechnology Approaches to Improving Cancer Immunotherapy

C Tilden Hagan 4th¹, Yusra B Medik², Andrew Z Wang³

Affiliations

¹ Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
² Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
³ Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: zawang@med.unc.edu.

PMID: 29941106
PMCID: PMC11811840
DOI: 10.1016/bs.acr.2018.05.003

Review

Nanotechnology Approaches to Improving Cancer Immunotherapy

C Tilden Hagan 4th et al. Adv Cancer Res. 2018.

. 2018:139:35-56.

doi: 10.1016/bs.acr.2018.05.003. Epub 2018 Jun 7.

Authors

C Tilden Hagan 4th¹, Yusra B Medik², Andrew Z Wang³

Affiliations

¹ Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
² Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
³ Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: zawang@med.unc.edu.

PMID: 29941106
PMCID: PMC11811840
DOI: 10.1016/bs.acr.2018.05.003

Abstract

Cancer immunotherapy is a powerful, growing treatment approach to cancer that can be combined with chemotherapy, radiotherapy, and oncosurgery. Modulating the immune system to enhance anticancer response by several strategies has yielded improved cancer survival. Despite this progress, the success rate for immunotherapy has been below expectations due to unpredictable efficacy and off-target side effects from systemic dosing. Nanotechnology offers numerous different materials and targeting properties to overcome many of these challenges in immunotherapy. In this chapter, we review current immunotherapy and its challenges as well as the latest nanotechnology applications in cancer immunotherapy.

Keywords: Cancer immunotherapy; Immune resistance; Nanoparticles; Nanotechnology; Tumor microenvironment.

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Figures

**Fig. 1**
Immunosuppressive tumor microenvironment and immunotherapies.

**Fig. 2**
Nanoparticles for cancer immunotherapy. Nanoparticles with different structures can be used cancer immunotherapy, which includes (A) dendrimer, (B) polymeric micelles, (C) virus-like nanoparticles, (D) liposomes, (E) gold nanoparticles, etc.

See this image and copyright information in PMC

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Nanotechnology Approaches to Improving Cancer Immunotherapy

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Nanotechnology Approaches to Improving Cancer Immunotherapy

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