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Review
. 2018 Nov-Dec;84(6):790-798.
doi: 10.1016/j.bjorl.2018.05.002. Epub 2018 Jun 11.

Solitary plasmacytoma of the jaws: therapeutical considerations and prognosis based on a case reports systematic survey

Eduardo Madruga Lombardo  1 , Fábio Luiz Dal Moro Maito  2 , Cláiton Heitz  3
Affiliations
Review

Solitary plasmacytoma of the jaws: therapeutical considerations and prognosis based on a case reports systematic survey

Eduardo Madruga Lombardo et al. Braz J Otorhinolaryngol. 2018 Nov-Dec.

Abstract
in English, Portuguese

Introduction: Solitary plasmacytoma is a rare malignant tumor of plasma cells with no evidence of systemic proliferation. There are two known subtypes: extramedullary solitary plasmacytoma and solitary bone plasmacytoma. The etiology is still unknown. Both lesions present a risk of progression to multiple myeloma. A number of approaches have been used for treatment of solitary plasmacytoma.

Objective: To carry out a systematic review of the case reports described in the literature, focusing on therapeutic and prognostic aspects.

Methods: A search of clinical case reports was performed in the PubMed database using Mesh Terms related to "plasmacytoma" under the following criteria: type of study (case report), articles in English language, conducted in humans, with no publication date limits.

Results: Of the 216 articles found, only 21 articles met the pre-established inclusion criteria.

Conclusion: The occurrence of solitary bone plasmacytoma in the bones of the face is a rare condition prevalent between the 4th and 6th decades of life, located in the posterior region of the mandible in most cases. Histopathological examination and systemic investigation are mandatory for confirmation of diagnosis.

Introdução: O plasmocitoma solitário é um tumor maligno raro de células plasmáticas sem evidência de proliferação sistêmica e engloba dois subtipos: plasmocitoma solitário extramedular e plasmocitoma solitário ósseo. A etiologia ainda é desconhecida. Ambas as lesões apresentam risco de progressão para mieloma múltiplo. Uma série de abordagens tem sido usada para seu tratamento.

Objetivo: Realizar uma revisão sistemática da literatura com enfoque nos aspectos terapêuticos e prognósticos.

Método: Realizou-se uma busca de relatos de caso clínico na base de dados PubMed com termos de busca relacionados com “plasmocitoma” sob os seguintes critérios: tipo de estudo (relato de caso), artigos na língua inglesa, estudos realizados apenas em humanos, sem limites de data de publicação.

Resultados: Dos 216 artigos encontrados, apenas 21 artigos preencheram os critérios de inclusão pré-estabelecidos.

Conclusão: A ocorrência de plasmocitoma solitário ósseo nos ossos da face é uma condição rara prevalente entre a 4a e a 6a décadas de vida, localizada na região posterior de mandíbula na maioria dos casos. O exame histopatológico e a investigação sistêmica são mandatórios para confirmação do diagnóstico.

Keywords: Mieloma múltiplo; Multiple myeloma; Plasma cell tumor; Plasmacytoma; Plasmocitoma; Tumor de células plasmáticas.

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