Effect of trazodone on oxidative metabolism of rat brain in vitro
- PMID: 2994183
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Effect of trazodone on oxidative metabolism of rat brain in vitro
Rev Esp Fisiol.
1985 Jun.
Abstract
Oxygen uptake of rat brain homogenate was reduced by 1 mM trazodone, a new atypical antidepressant. Na,K-ATPase activity and the associated oxygen consumption of rat brain slices were also reduced. Oxygen consumption of rat brain slices was enhanced by dopamine and this effect was blocked by 0.0001 mM trazodone. This drug uncoupled oxidative phosphorylation.
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