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. 1985 Jun;41(2):201-5.

Effect of trazodone on oxidative metabolism of rat brain in vitro

A Velasco, V González-Calvo, F J Alvarez, A Dueñas, J L García-Roldán
  • PMID: 2994183

Effect of trazodone on oxidative metabolism of rat brain in vitro

A Velasco et al. Rev Esp Fisiol. 1985 Jun.

Abstract

Oxygen uptake of rat brain homogenate was reduced by 1 mM trazodone, a new atypical antidepressant. Na,K-ATPase activity and the associated oxygen consumption of rat brain slices were also reduced. Oxygen consumption of rat brain slices was enhanced by dopamine and this effect was blocked by 0.0001 mM trazodone. This drug uncoupled oxidative phosphorylation.

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