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. 2018 Jun;11(3):315-329.
doi: 10.1093/ckj/sfx122. Epub 2017 Oct 27.

Risk factors associated with post-kidney transplant malignancies: an article from the Cancer-Kidney International Network

Ben Sprangers  1   2   3 , Vinay Nair  4 , Vincent Launay-Vacher  3   5 , Leonardo V Riella  6 , Kenar D Jhaveri  3   4
Affiliations

Risk factors associated with post-kidney transplant malignancies: an article from the Cancer-Kidney International Network

Ben Sprangers et al. Clin Kidney J. 2018 Jun.

Abstract

In kidney transplant recipients, cancer is one of the leading causes of death with a functioning graft beyond the first year of kidney transplantation, and malignancies account for 8-10% of all deaths in the USA (2.6 deaths/1000 patient-years) and exceed 30% of deaths in Australia (5/1000 patient-years) in kidney transplant recipients. Patient-, transplant- and medication-related factors contribute to the increased cancer risk following kidney transplantation. While it is well established that the overall immunosuppressive dose is associated with an increased risk for cancer following transplantation, the contributive effect of different immunosuppressive agents is not well established. In this review we will discuss the different risk factors for malignancies after kidney transplantation.

Keywords: immunosuppression; kidney transplantation; malignancy; risk factor.

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Figures

Fig. 1.
Fig. 1.
Cancerogenesis following kidney transplantation (adapted from Riella [37]).
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