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. 2018 Jun 14:9:50.
doi: 10.1186/s40104-018-0261-1. eCollection 2018.

Feed conversion ratio, residual feed intake and cholecystokinin type A receptor gene polymorphisms are associated with feed intake and average daily gain in a Chinese local chicken population

Zhenhua Yi #  1   2 , Xing Li #  1   2 , Wen Luo  1   2 , Zhenqiang Xu  3 , Congliang Ji  3 , Yan Zhang  3 , Qinghua Nie  1   2 , Dexiang Zhang  1   2   3 , Xiquan Zhang  1   2
Affiliations

Feed conversion ratio, residual feed intake and cholecystokinin type A receptor gene polymorphisms are associated with feed intake and average daily gain in a Chinese local chicken population

Zhenhua Yi et al. J Anim Sci Biotechnol. .

Abstract

Background: The feed conversion ratio (FCR) and residual feed intake (RFI) are common indexes in measuring feed efficiency for livestock. RFI is a feed intake adjusted for requirements for maintenance and production so these two traits are related. Similarly, FCR is related to feed intake and weight gain because it is their ratio. Cholecystokinin type A receptor (CCKAR) plays an important role in animal digestive process. We examined the interplay of these three parameters in a local Chinese chicken population.

Results: The feed intake (FI) and body weights (BW) of 1,841 individuals were monitored on a daily basis from 56 to 105 d of age. There was a strong correlation between RFI and average daily feed intake (ADFI) and a negative correlation between the FCR and daily gain (rg = - 0.710). Furthermore, we identified 51 single nucleotide polymorphisms (SNPs) in the CCKAR and 4 of these resulted in amino acid mutations. The C334A mutation was specifically associated with FI and the expected feed intake (EFI) (P < 0.01) and significantly associated with the average daily gain (ADG) (P < 0.05). G1290A was significantly associated with FI and EFI (P < 0.05).

Conclusion: FCR is apply to weight selecting, and RFI is more appropriate if the breeding focus is feed intake. And C334A and G1290A of the CCKAR gene can be deemed as candidate markers for feed intake and weight gain.

Keywords: CCKAR; Chicken; FCR; RFI; SNP.

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Conflict of interest statement

All experimental protocols were approved by the South China Agricultural University Institutional Animal Care and Use Committee (Guangzhou, People’s Republic of China). Animals involved in this study were humanely sacrificed as necessary to ameliorate their suffering.The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The weekly average weight of chickens during the experimental period
Fig. 2
Fig. 2
Comparison between ADFI and EFI. Points above the dotted line represent low RFI individuals with high energy utilization and below the line represent high RFI individuals with poor energy utilization
Fig. 3
Fig. 3
Distribution of 51 SNPs in the chicken CCKAR gene The pale green regions represent untranslated regions; the dark green regions represent exons. The red regions represent the SNPs sites. The first nucleotide of the translation start codon was designated + 1
Fig. 4
Fig. 4
Linkage disequilibrium analysis of SNPs in the study population
See this image and copyright information in PMC

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