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Case Reports
. 2018 Mar 14:12:49-52.
doi: 10.1016/j.idcr.2018.03.012. eCollection 2018.

Salmonella Enteritidis cholecystitis with chronic granulomatous disease

Yuki Yamashita  1 , Takefumi Kimura  1 , Naoki Tanaka  2 , Masahide Yazaki  3 , Tadashi Itagaki  4 , Satoru Joshita  1 , Takeji Umemura  1 , Akihiro Matsumoto  1 , Hiromitsu Mori  4 , Shuichi Wada  4 , Eiji Tanaka  1
Affiliations
Case Reports

Salmonella Enteritidis cholecystitis with chronic granulomatous disease

Yuki Yamashita et al. IDCases. .

Abstract

We describe a 40-year-old woman with Salmonella cholecystitis complicating adult-onset X-linked chronic granulomatous disease (CGD) caused by a de novo mutation in the paternal-origin CYBB gene. CGD was diagnosed by familial genetic analysis of the CYBB gene encoding NADPH oxidase gp91phox after detection of a refractory subcutaneous abscess at the age of 28. At age 40, she began experiencing frequent fever and diarrhea over a period of 3 months that were refractory to antibacterial treatment. Cholecystitis was evident. Her symptoms improved after percutaneous trans-hepatic gallbladder aspiration puncture with stand-by cholecystectomy. Salmonella enterica serotype Enteritidis (S. Enteritidis) was detected in blood, stool, and bile acid samples. Due to her suppressed bactericidal ability caused by CGD, S. Enteritidis was considered to have translocated from the gut to reside in the gallbladder, causing her repeated enteritis and sepsis. When encountering CGD with recurrent salmonellosis, the possibility of cholecystitis should be considered as another infection focus.

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Figures

Fig. 1
Fig. 1
Abdominal ultrasound on admission revealed a distended gallbladder, thickening of the gallbladder wall, and biliary sludge (arrowheads).
Fig. 2
Fig. 2
Abdominal contrast CT on admission demonstrated edematous change of the gallbladder, early patchy enhancement of the liver (arrowheads), and edematous change of the intestinal tract (arrows).
Fig. 3
Fig. 3
Drained purulent bile by percutaneous trans-hepatic gallbladder aspiration puncture.
See this image and copyright information in PMC

References

    1. Gono T., Yazaki M., Agematsu K., Matsuda M., Yasui K., Yamaura M. Adult onset x-linked chronic granulomatous disease in a woman patient caused by a de novo mutation in paternal-origin cybb gene and skewed inactivation of normal maternal x chromosome. Intern Med. 2008;47:1053–1056. - PubMed
    1. Roos D. Chronic granulomatous disease. Br Med Bull. 2016;118:50–63. - PMC - PubMed
    1. Lun A., Roesler J., Renz H. Unusual late onset of x-linked chronic granulomatous disease in an adult woman after unsuspicious childhood. Clin Chem. 2002;48:780–781. - PubMed
    1. Wolach B., Scharf Y., Gavrieli R., de Boer M., Roos D. Unusual late presentation of x-linked chronic granulomatous disease in an adult female with a somatic mosaic for a novel mutation in cybb. Blood. 2005;105:61–66. - PubMed
    1. Burniat W., Toppet M., De Mol P. Acute and recurrent salmonella infections in three children with chronic granulomatous disease. J Infect. 1980;2:263–268. - PubMed

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