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Multicenter Study
. 2018 Jun 27;19(1):129.
doi: 10.1186/s12931-018-0823-y.

Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study

Carl M Philpott  1   2 , Sally Erskine  3 , Claire Hopkins  4 , Nirmal Kumar  5 , Shahram Anari  6 , Naveed Kara  7 , Sankalp Sunkaraneni  8 , Jaydip Ray  9 , Allan Clark  10 , Andrew Wilson  10 ; CRES group; Sally Erskine, Carl Philpott, Allan Clark, Claire Hopkins, Alasdair Robertson, Shahzada Ahmed, Naveed Kara, Sean Carrie, Vishnu Sunkaraneni, Jaydip Ray, Shahram Anari, Paul Jervis, Jaan Panesaar, Amir Farboud, Nirmal Kumar, Russell Cathcart, Robert Almeyda, Hisham Khalil, Peter Prinsley, Nicolas Mansell, Mahmoud Salam, Jonathan Hobson, Jane Woods, Emma Coombes
Affiliations
Multicenter Study

Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study

Carl M Philpott et al. Respir Res. .

Abstract

Background: Chronic rhinosinusitis (CRS) is a common disorder associated with other respiratory tract diseases such as asthma and inhalant allergy. However, the prevalence of these co-morbidities varies considerably in the existing medical literature and by phenotype of CRS studied. The study objective was to identify the prevalence of asthma, inhalant allergy and aspirin sensitivity in CRS patients referred to secondary care and establish any differences between CRS phenotypes.

Methods: All participants were diagnosed in secondary care according to international guidelines and invited to complete a questionnaire including details of co-morbidities and allergies. Data were analysed for differences between controls and CRS participants and between phenotypes using chi-squared tests.

Results: The final analysis included 1470 study participants: 221 controls, 553 CRS without nasal polyps (CRSsNPs), 651 CRS with nasal polyps (CRSwNPs) and 45 allergic fungal rhinosinusitis (AFRS). The prevalence of asthma was 9.95, 21.16, 46.9 and 73.3% respectively. The prevalence of self-reported confirmed inhalant allergy was 13.1, 20.3, 31.0 and 33.3% respectively; house dust mite allergy was significantly higher in CRSwNPs (16%) compared to CRSsNPs (9%, p < 0.001). The prevalence of self- reported aspirin sensitivity was 2.26, 3.25, 9.61 and 40% respectively. The odds ratio for aspirin sensitivity amongst those with AFRS was 28.8 (CIs 9.9, 83.8) p < 0.001.

Conclusions: The prevalence of asthma and allergy in CRS varies by phenoytype, with CRSwNPs and AFRS having a stronger association with both. Aspirin sensitivity has a highly significant association with AFRS. All of these comorbidities are significantly more prevalent than in non-CRS controls and strengthen the need for a more individualised approach to the combined airway.

Keywords: Allergy; Aspirin sensitivity; Asthma; Epidemiology; Quality of life; Rhinitis; Rhinosinusitis; Sinusitis.

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Conflict of interest statement

Ethics approval and consent to participate

The CRES was approved by the Oxford C Research Ethics Committee (Ref: 07/H0606/100), sponsored by the University of East Anglia (UEA).

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Participant Flow
Fig. 2
Fig. 2
Frequency of confirmed inhalant allergy in CRS participants
See this image and copyright information in PMC

References

    1. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P, et al: European position paper on rhinosinusitis and nasal polyps 2012. Rhinol Suppl 2012:3 p preceding table of contents, 1–298. - PubMed
    1. Hastan D, Fokkens WJ, Bachert C, Newson RB, Bislimovska J, Bockelbrink A, Bousquet PJ, Brozek G, Bruno A, Dahlén SE, et al. Chronic rhinosinusitis in Europe – an underestimated disease. A GA2LEN study. Allergy. 2011;66:1216–1223. doi: 10.1111/j.1398-9995.2011.02646.x. - DOI - PubMed
    1. Safirstein BH. ALlergic bronchopulmonary aspergillosis with obstruction of the upper respiratory tract. Chest. 1976;70:788–790. doi: 10.1378/chest.70.6.788. - DOI - PubMed
    1. Bent JP, 3rd, Kuhn FA. Diagnosis of allergic fungal sinusitis. Otolaryngol Head Neck Surg. 1994;111:580–588. doi: 10.1177/019459989411100508. - DOI - PubMed
    1. Stevenson DD, Szczeklik A. Clinical and pathologic perspectives on aspirin sensitivity and asthma. J Allergy Clin Immunol. 2006;118:773–786. doi: 10.1016/j.jaci.2006.07.024. - DOI - PubMed

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