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. 2018 Jun 20;21(6):458-462.
doi: 10.3779/j.issn.1009-3419.2018.06.06.

[Severe Adverse Reactions Induced by the Chest Injection of Elemene: An Analysis of 7 Cases]

[Article in Chinese]
Fei Gao  1 , Yi Shao  1 , Diansheng Zhong  1 , Xia Liu  1 , Fanlu Meng  1
Affiliations

[Severe Adverse Reactions Induced by the Chest Injection of Elemene: An Analysis of 7 Cases]

[Article in Chinese]
Fei Gao et al. Zhongguo Fei Ai Za Zhi. .

Abstract
in English, Chinese

Background: Malignant pleural effusion (MPE) refers to pleural effusion which arises from primary malignant tumor of pleura or other pleural metastatic tumors. Injection of elemene in chest makes good effect on the treatment of MPE, and is widely used in clinic. Adverse effects also exist, but the severe adverse effects and relevant managements are rarely reported. The aim of this study is to observe the adverse reactions induced by the treatment of malignant pleural effusion through elemene injection and to explore the solutions.

Methods: A retrospective analysis was made on 14 cases of patients receiving intra-pleural injections with elemene, and the incidence of severe adverse reactions of 7 cases were disscussed in detail.

Results: Most of the severe adverse reactions caused by elemene were severe chest pain, dyspnea, wheezing, clouding of consciousness and coagulopathy.

Conclusions: Strict screening, full preprocessing and close monitoring are necessary to prevent serious adverse reactions caused by elemene injection in the treatment of malignant pleural effusion.

【中文题目：胸腔注射榄香烯致严重不良反应7例病例 系列分析】 【中文摘要：背景与目的 恶性胸腔积液（malignant pleural effusion, MPE）指胸膜原发恶性肿瘤或其他部位恶性肿瘤转移至胸膜引起的胸腔积液。胸腔内注射榄香烯对MPE有良好的治疗效果，在临床中应用较普遍，同时存在一些不良反应，但文献缺乏对严重不良反应的报道及处理。本研究旨在观察榄香烯注射液治疗恶性胸腔积液导致不良反应发生情况，探讨严重不良反应发生原因和应对方案。方法 回顾性分析14例胸腔注射榄香烯病例，对其中7例发生严重不良反应病例进行详细报道。结果 榄香烯注射液胸腔注射所致严重不良反应主要表现为剧烈胸痛、呼吸困难、喘憋、意识模糊和凝血功能障碍，经临床对症治疗后均可缓解。结论 胸腔注射榄香烯榄香烯对MPE有一定治疗价值，使用时应严格把握适应证、筛选患者、严密监测。 】 【中文关键词：榄香烯注射液；胸腔注射；不良反应；恶性胸腔积液；呼吸困难】.

Keywords: Adverse reactions; Chest injection; Dyspnea; Elemene injection; Malignant pleural effusion.

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