doi: 10.1007/BF00447066.
Evidence for cAMP-mediated control of isoleucyl-tRNA synthetase formation in Escherichia coli K-12
- PMID: 2994589
- DOI: 10.1007/BF00447066
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Evidence for cAMP-mediated control of isoleucyl-tRNA synthetase formation in Escherichia coli K-12
Arch Microbiol.
1985 Jul.
Abstract
The ability of cAMP to inhibit isoleucyl-tRNA synthetase (IRS) formation has been demonstrated in wild type K-12 Escherichia coli and two adenyl-cyclase (cya) mutants. cAMP appeared not to have any effect on either the valyl- or arginyl-tRNA synthetase (VRS and ARS respectively). Addition of cAMP led to a reduction in rate of IRS synthesis but not VRS or ARS. Furthermore, derepression of IRS and VRS by isoleucine limitation was completely prevented by cAMP.
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