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Randomized Controlled Trial
. 2018 Jun 26;8(1):9713.
doi: 10.1038/s41598-018-27950-9.

Metformin add-on continuous subcutaneous insulin infusion on precise insulin doses in patients with type 2 diabetes

Feng-Fei Li  1 , Bing-Li Liu  1 , Guo-Ping Yin  1 , Reng-Na Yan  1 , Dan-Feng Zhang  1 , Jin-Dan Wu  1 , Lei Ye  2 , Xiao-Fei Su  1 , Jian-Hua Ma  3
Affiliations
Randomized Controlled Trial

Metformin add-on continuous subcutaneous insulin infusion on precise insulin doses in patients with type 2 diabetes

Feng-Fei Li et al. Sci Rep. .

Abstract

To investigate whether metformin add-on to the continuous subcutaneous insulin infusion (Met + CSII) therapy leads to a significant reduction in insulin doses required by type 2 diabetes (T2D) patients to maintain glycemic control, and an improvement in glycemic variation (GV) compared to CSII only therapy. We analyzed data from our two randomized, controlled open-label trials. Newly diagnoses T2D patients were randomized assigned to receive either CSII therapy or Met + CSII therapy for 4 weeks. Subjects were subjected to a 4-day continuous glucose monitoring (CGM) at the endpoint. Insulin doses and GV profiles were analyzed. The primary endpoint was differences in insulin doses and GV between the two groups. A total of 188 subjects were admitted as inpatients. Subjects in metformin add-on therapy required significantly lower total, basal and bolus insulin doses than those of control group. CGM data showed that patients in Met + CSII group exhibited significant reduction in the 24-hr mean amplitude of glycemic excursions (MAGE), the standard deviation, and the coefficient of variation compared to those of control group. Our data suggest that metformin add-on to CSII therapy leads to a significant reduction in insulin doses required by T2D patients to control glycemic variations.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The hourly glucose concentrations in patients between the two groups,*compared with control Group (P < 0.05).
See this image and copyright information in PMC

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