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. 2018 May 9;15(3):747-753.
doi: 10.1016/j.jor.2018.05.047. eCollection 2018 Sep.

Association of TNF-α-308 G > A and -238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis

Mohammad Reza Sobhan  1 , Masoud Mahdinezhad-Yazdi  2 , Kazem Aghili  3 , Masoud Zare-Shehneh  4 , Shohreh Rastegar  5 , Jalal Sadeghizadeh-Yazdi  6 , Hossein Neamatzadeh  4
Affiliations

Association of TNF-α-308 G > A and -238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis

Mohammad Reza Sobhan et al. J Orthop. .

Abstract

Objective: A comprehensive search on electronic databases was conducted to identify all eligible studies of TNF-α polymorphisms and knee osteoarthritis (OA).

Methods: Eight studies on TNF-α -308 G > A and three on TNF-α -238G > A polymorphism were identified.

Results: Overall, the pooled ORs indicated that neither TNF-α -238G > A nor -238G > A polymorphism was associated with knee OA risk. Similarly, in the stratified analysis by ethnicity, no significant association was found.

Conclusion: This meta-analysis results inconsistent with the previous meta-analyses showed that the TNF-α -308 G > A and -238G > A polymorphisms may not be associated with the susceptibility to knee OA.

Keywords: Knee; Meta-analysis; Osteoarthritis; Polymorphism; Tumor necrosis factor-alpha.

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Figures

Fig. 1
Fig. 1
Flow diagram of the study selection process.
Fig. 2
Fig. 2
Forest plots of the association between TNF-α −308 G > A polymorphism with knee OA. (A) the allele model (A vs. G); and (B) the dominant model (AA + AG vs. GG).
Fig. 3
Fig. 3
Funnel plot analysis to detect publication bias for TNF-α −308 G > A polymorphism under the allele model.
See this image and copyright information in PMC

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