Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018:1063:3-12.
doi: 10.1007/978-3-319-77736-8_1.

Glucose Metabolism in Cancer

Sminu Bose  1 , Anne Le  2
Affiliations
Review

Glucose Metabolism in Cancer

Sminu Bose et al. Adv Exp Med Biol. 2018.

Abstract

Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells derived the energy required for uncontrolled replication from proteolysis and lipolysis, Warburg instead found them to rapidly consume glucose, converting it to lactate [1]. The significance of this finding, later termed the Warburg effect, went unnoticed by the larger scientific community at that time. The field of cancer metabolism lay dormant for almost a century awaiting advances in molecular biology and genetics which would later open the doors to new cancer therapies.

Keywords: Cancer metabolism; Gluconeogenesis; Glucose metabolism; Glycogenolysis; Warburg effect.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Science. 1956 Feb 24;123(3191):309-14 - PubMed
    1. Br J Cancer. 2003 Sep 1;89(5):877-85 - PubMed
    1. J Natl Cancer Inst. 2014 Apr 03;106(5):null - PubMed
    1. Cell Death Discov. 2015 Sep 07;1:15016 - PubMed
    1. Expert Opin Ther Targets. 2009 Dec;13(12):1411-27 - PubMed

LinkOut - more resources