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. 2018 Aug;596(15):2935-2938.
doi: 10.1113/JP275707. Epub 2018 Jun 27.

CrossTalk proposal: a central hypoxia sensor contributes to the excitatory hypoxic ventilatory response

Gregory D Funk  1 , Alexander V Gourine  2
Affiliations

CrossTalk proposal: a central hypoxia sensor contributes to the excitatory hypoxic ventilatory response

Gregory D Funk et al. J Physiol. 2018 Aug.
No abstract available

Keywords: astrocyte; control of breathing; hypoxia; purinergic receptor.

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Figures

Figure 1
Figure 1. Attenuation of the hypoxic ventilatory response by disruption of vesicular release mechanisms in preBötC astrocytes
A, ventilatory responses of young and older (anaesthetized) piglets to hypoxia (6%) (modified with permission from Moss, RA. Respir Physiol (2000) 121, 185–197). B, summary data illustrating hypoxia‐induced changes in minute lung ventilation in carotid body intact and peripherally chemodenervated (10 weeks) conscious rats expressing CatCh (calcium translocating channel rhodopsin variant that was fused with EGFP and used as a control here) or TeLC bilaterally within astrocytes of the preBötC network. Ventilation measurements were obtained during the last 5 min of the 10 min hypoxia period. TeLC caused similar reductions in the HVR of intact and CB‐denervated rats (modified with permission from Angelova et al. 2015).
See this image and copyright information in PMC

Comment in

  • Rebuttal from Luc J. Teppema.
    Teppema LJ. Teppema LJ. J Physiol. 2018 Aug;596(15):2945. doi: 10.1113/JP276281. Epub 2018 Jun 26. J Physiol. 2018. PMID: 29947023 Free PMC article. No abstract available.

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