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. 2018 Aug;109(4):280-284.
doi: 10.23736/S0026-4806.18.05572-6.

Benign prostatic hypertrophy: Pycnogenol® supplementation improves prostate symptoms and residual bladder volume

Andrea Ledda  1   2 , Gianni Belcaro  3   2 , Beatrice Feragalli  1   2 , Umberto Cornelli  1   2 , Mark Dugall  1   2 , Marcello Corsi  1   2 , Maria R Cesarone  1   2
Affiliations

Benign prostatic hypertrophy: Pycnogenol® supplementation improves prostate symptoms and residual bladder volume

Andrea Ledda et al. Minerva Med. 2018 Aug.

Abstract

Background: The aim of this study was to evaluate the efficacy of Pycnogenol® supplementation in terms of safety and tolerability in the setting of preclinical or borderline, initial symptoms of benign prostatic hyperthrophy (BPH), in otherwise healthy subjects, using Pycnogenol® over a period of 60 days.

Methods: Seventy-five healthy men with symptoms and signs of initial BPH were included. The subjects were divided into three groups: 1) control group using only the standard management (SM); 2) a group using SM plus Pycnogenol® 150 mg/day; 3) a group using standard pharmacological management.

Results: BPH symptoms like emptying, frequency, intermittency, urgency, weak flow, straining, nocturia, were all significantly improved with Pycnogenol® (P<0.05) and the difference with both control groups was statistically significant (P<0.05).

Conclusions: Pycnogenol® may be an important option for self-management of BPH in otherwise healthy men.

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