Reprogramming Halomonas for industrial production of chemicals

Xiangbin Chen^{1

2

3}, Linping Yu^{1

2

3}, Guanqing Qiao^{1

2

3}, Guo-Qiang Chen^{4

5

6

7}

Affiliations

¹ MOE Lab of Bioinformatics, School of Life Sciences, Tsinghua University, 100084, Beijing, China.
² Center for Synthetic and Systems Biology, Tsinghua University, 100084, Beijing, China.
³ Tsinghua-Peking Center for Life Sciences, Tsinghua University, 100084, Beijing, China.
⁴ MOE Lab of Bioinformatics, School of Life Sciences, Tsinghua University, 100084, Beijing, China. chengq@mail.tsinghua.edu.cn.
⁵ Center for Synthetic and Systems Biology, Tsinghua University, 100084, Beijing, China. chengq@mail.tsinghua.edu.cn.
⁶ Tsinghua-Peking Center for Life Sciences, Tsinghua University, 100084, Beijing, China. chengq@mail.tsinghua.edu.cn.
⁷ Manchester Institute of Biotechnology, Centre for Synthetic Biology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK. chengq@mail.tsinghua.edu.cn.

PMID: 29948194
DOI: 10.1007/s10295-018-2055-z

Reprogramming Halomonas for industrial production of chemicals

Xiangbin Chen et al. J Ind Microbiol Biotechnol. 2018 Jul.

. 2018 Jul;45(7):545-554.

doi: 10.1007/s10295-018-2055-z. Epub 2018 Jun 8.

Authors

Xiangbin Chen^{1

2

3}, Linping Yu^{1

2

3}, Guanqing Qiao^{1

2

3}, Guo-Qiang Chen^{4

5

6

7}

Affiliations

¹ MOE Lab of Bioinformatics, School of Life Sciences, Tsinghua University, 100084, Beijing, China.
² Center for Synthetic and Systems Biology, Tsinghua University, 100084, Beijing, China.
³ Tsinghua-Peking Center for Life Sciences, Tsinghua University, 100084, Beijing, China.
⁴ MOE Lab of Bioinformatics, School of Life Sciences, Tsinghua University, 100084, Beijing, China. chengq@mail.tsinghua.edu.cn.
⁵ Center for Synthetic and Systems Biology, Tsinghua University, 100084, Beijing, China. chengq@mail.tsinghua.edu.cn.
⁶ Tsinghua-Peking Center for Life Sciences, Tsinghua University, 100084, Beijing, China. chengq@mail.tsinghua.edu.cn.
⁷ Manchester Institute of Biotechnology, Centre for Synthetic Biology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK. chengq@mail.tsinghua.edu.cn.

PMID: 29948194
DOI: 10.1007/s10295-018-2055-z

Abstract

Halomonas spp. are able to grow under a high salt concentration at alkali pH, they are able to resist contamination by other microbes. Development of Halomonas spp. as platform production strains for the next-generation industrial biotechnology (NGIB) is intensively studied. Among Halomonas spp., Halomonas bluephagenesis is the best studied one with available engineering tools and methods to reprogram it for production of various polyhydroxyalkanoates, proteins, and chemicals. Due to its contamination resistance, H. bluephagenesis can be grown under open and continuous processes not just in the labs but also in at least 1000 L fermentor scale. It is expected that NGIB based on Halomonas spp. be able to engineer for production of increasing number of products in a competitive manner.

Keywords: Chromosome engineering; Halomonas; NGIB; Next-generation industrial biotechnology; PHB; Polyhydroxyalkanoates.

PubMed Disclaimer

Cited by

Mobile and Self-Sustained Data Storage in an Extremophile Genomic DNA.
Sun F, Dong Y, Ni M, Ping Z, Sun Y, Ouyang Q, Qian L. Sun F, et al. Adv Sci (Weinh). 2023 Apr;10(10):e2206201. doi: 10.1002/advs.202206201. Epub 2023 Feb 3. Adv Sci (Weinh). 2023. PMID: 36737843 Free PMC article.
The important versus the exciting: reining contradictions in contemporary biotechnology.
de Lorenzo V, Couto J. de Lorenzo V, et al. Microb Biotechnol. 2019 Jan;12(1):32-34. doi: 10.1111/1751-7915.13348. Epub 2018 Dec 3. Microb Biotechnol. 2019. PMID: 30508281 Free PMC article. No abstract available.
Stress-tolerant non-conventional microbes enable next-generation chemical biosynthesis.
Thorwall S, Schwartz C, Chartron JW, Wheeldon I. Thorwall S, et al. Nat Chem Biol. 2020 Feb;16(2):113-121. doi: 10.1038/s41589-019-0452-x. Epub 2020 Jan 23. Nat Chem Biol. 2020. PMID: 31974527 Review.
Effects of sugarcane variety and nitrogen application level on the quality and aerobic stability of sugarcane tops silage.
Gu Q, Zhang L, Zhou X, Lin B, Zou C. Gu Q, et al. Front Plant Sci. 2023 May 30;14:1148884. doi: 10.3389/fpls.2023.1148884. eCollection 2023. Front Plant Sci. 2023. PMID: 37324669 Free PMC article.
Complete genome sequencing and comparison of two nitrogen-metabolizing bacteria isolated from Antarctic deep-sea sediment.
Liu W, Cong B, Lin J, Zhao L, Liu S. Liu W, et al. BMC Genomics. 2022 Oct 19;23(1):713. doi: 10.1186/s12864-022-08942-6. BMC Genomics. 2022. PMID: 36261793 Free PMC article.

See all "Cited by" articles

References

1. J Appl Microbiol. 2007 Nov;103(5):1716-27 - PubMed
1. Nucleic Acids Res. 2013 Jan;41(Database issue):D666-75 - PubMed
1. Biotechnol Adv. 2010 Jul-Aug;28(4):436-50 - PubMed
1. Metab Eng. 2018 May;47:219-229 - PubMed
1. Biotechnol Adv. 2015 Nov 15;33(7):1433-42 - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Reprogramming Halomonas for industrial production of chemicals

Affiliations

Reprogramming Halomonas for industrial production of chemicals

Authors

Affiliations

Abstract

Similar articles

Cited by

References

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous