Can HbA1c combined with fasting plasma glucose help to assess priority for GCK-MODY vs HNF1A-MODY genetic testing?

Maurizio Delvecchio¹, Giuseppina Salzano², Clara Bonura³, Vittoria Cauvin⁴, Valentino Cherubini⁵, Giuseppe d'Annunzio⁶, Adriana Franzese⁷, Sabrina Giglio⁸, Valeria Grasso⁹, Vanna Graziani¹⁰, Dario Iafusco¹¹, Lorenzo Iughetti¹², Riccardo Lera¹³, Claudio Maffeis¹⁴, Giulio Maltoni¹⁵, Vilma Mantovani¹⁶, Claudia Menzaghi¹⁷, Patrizia I Patera¹⁸, Ivana Rabbone¹⁹, Petra Reindstadler²⁰, Sabrina Scelfo²¹, Nadia Tinto²², Sonia Toni²³, Stefano Tumini²⁴, Fortunato Lombardo², Antonio Nicolucci²⁵, Fabrizio Barbetti^{26

27}; Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetes (ISPED)

Affiliations

¹ Pediatric and Neonatology Unit, Mother and Children Health Care Department, "Madonna delle Grazie" Hospital, ASL Matera, Contrada Cattedra Ambulante, 85100, Matera, Italy. mdelvecchio75@gmail.com.
² Department of Pediatric Sciences, University of Messina, Messina, Italy.
³ Endocrine Unit, Department of Pediatrics, Diabetes Research Institute (OSR-DRI), Scientific Institute Hospital San Raffaele, Milan, Italy.
⁴ Pediatric Diabetology Unit, S. Chiara Hospital, Trento, Italy.
⁵ S.O.D. Pediatric Diabetology, Department of Women's and Children Health, Salesi Hospital, Ancona, Italy.
⁶ Istituto Giannina Gaslini, Regional Center for Pediatric Diabetes, Genoa, Italy.
⁷ Regional Center of Pediatric Diabetology, University of Naples Federico II, Naples, Italy.
⁸ Medical Genetics Unit, Department of Clinical and Experimental Biomedical Sciences "Mario Serio", and Meyer Children's University Hospital, University of Florence, Florence, Italy.
⁹ Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
¹⁰ Pediatric Unit, S. Maria delle Croci Hospital, AUSL della Romagna, Ravenna, Italy.
¹¹ Department of Pediatrics, Regional Center for Pediatric Diabetology "G.Stoppoloni", University of Campania "Luigi Vanvitelli", Naples, Italy.
¹² Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.
¹³ Department of Pediatrics, Alessandria Hospital, Alessandria, Italy.
¹⁴ Pediatric Diabetes and Metabolic Disorders Unit, Department of Surgical Science, Dentistry, Ginecology and Pediatrics, University of Verona, Verona, Italy.
¹⁵ Department of Pediatrics, S. Orsola-Malpighi University Hospital, Bologna, Italy.
¹⁶ Center for Applied Biomedical Research (CRBA) and Medical Genetics Unit, St. Orsola University Hospital, Bologna, Italy.
¹⁷ Research Unit of Diabetes and Endocrine Disease, IRCCS Casa del Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
¹⁸ Pediatric Diabetology Unit, University Department of Pediatric Medicine, Bambino Gesù Children Hospital, Rome, Italy.
¹⁹ Department of Pediatrics, Regina Margherita Children Hospital, Turin, Italy.
²⁰ Department of Pediatrics, General Hospital Bolzano, Bolzano, Italy.
²¹ Pediatric Diabetes Unit, Health Service of Caltanissetta, Caltanissetta, Italy.
²² Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, and CEINGE, Advanced Biotechnology, Naples, Italy.
²³ Juvenile Diabetes Center, Meyer Children's Hospital, Florence, Italy.
²⁴ Center of Pediatric Diabetology, University of Chieti, Chieti, Italy.
²⁵ CORESEARCH-Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy.
²⁶ Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy. fabrizio.barbetti@uniroma2.it.
²⁷ Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. fabrizio.barbetti@uniroma2.it.

PMID: 29948406
DOI: 10.1007/s00592-018-1179-y

Can HbA1c combined with fasting plasma glucose help to assess priority for GCK-MODY vs HNF1A-MODY genetic testing?

Maurizio Delvecchio et al. Acta Diabetol. 2018 Sep.

. 2018 Sep;55(9):981-983.

doi: 10.1007/s00592-018-1179-y. Epub 2018 Jun 13.

Authors

Affiliations

¹ Pediatric and Neonatology Unit, Mother and Children Health Care Department, "Madonna delle Grazie" Hospital, ASL Matera, Contrada Cattedra Ambulante, 85100, Matera, Italy. mdelvecchio75@gmail.com.
² Department of Pediatric Sciences, University of Messina, Messina, Italy.
³ Endocrine Unit, Department of Pediatrics, Diabetes Research Institute (OSR-DRI), Scientific Institute Hospital San Raffaele, Milan, Italy.
⁴ Pediatric Diabetology Unit, S. Chiara Hospital, Trento, Italy.
⁵ S.O.D. Pediatric Diabetology, Department of Women's and Children Health, Salesi Hospital, Ancona, Italy.
⁶ Istituto Giannina Gaslini, Regional Center for Pediatric Diabetes, Genoa, Italy.
⁷ Regional Center of Pediatric Diabetology, University of Naples Federico II, Naples, Italy.
⁸ Medical Genetics Unit, Department of Clinical and Experimental Biomedical Sciences "Mario Serio", and Meyer Children's University Hospital, University of Florence, Florence, Italy.
⁹ Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
¹⁰ Pediatric Unit, S. Maria delle Croci Hospital, AUSL della Romagna, Ravenna, Italy.
¹¹ Department of Pediatrics, Regional Center for Pediatric Diabetology "G.Stoppoloni", University of Campania "Luigi Vanvitelli", Naples, Italy.
¹² Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.
¹³ Department of Pediatrics, Alessandria Hospital, Alessandria, Italy.
¹⁴ Pediatric Diabetes and Metabolic Disorders Unit, Department of Surgical Science, Dentistry, Ginecology and Pediatrics, University of Verona, Verona, Italy.
¹⁵ Department of Pediatrics, S. Orsola-Malpighi University Hospital, Bologna, Italy.
¹⁶ Center for Applied Biomedical Research (CRBA) and Medical Genetics Unit, St. Orsola University Hospital, Bologna, Italy.
¹⁷ Research Unit of Diabetes and Endocrine Disease, IRCCS Casa del Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
¹⁸ Pediatric Diabetology Unit, University Department of Pediatric Medicine, Bambino Gesù Children Hospital, Rome, Italy.
¹⁹ Department of Pediatrics, Regina Margherita Children Hospital, Turin, Italy.
²⁰ Department of Pediatrics, General Hospital Bolzano, Bolzano, Italy.
²¹ Pediatric Diabetes Unit, Health Service of Caltanissetta, Caltanissetta, Italy.
²² Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, and CEINGE, Advanced Biotechnology, Naples, Italy.
²³ Juvenile Diabetes Center, Meyer Children's Hospital, Florence, Italy.
²⁴ Center of Pediatric Diabetology, University of Chieti, Chieti, Italy.
²⁵ CORESEARCH-Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy.
²⁶ Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy. fabrizio.barbetti@uniroma2.it.
²⁷ Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. fabrizio.barbetti@uniroma2.it.

PMID: 29948406
DOI: 10.1007/s00592-018-1179-y

No abstract available

Keywords: Differential diagnosis; Fasting plasma glucose; HbA1c; Maturity Onset Diabetes of the Young/MODY.

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Can HbA1c combined with fasting plasma glucose help to assess priority for GCK-MODY vs HNF1A-MODY genetic testing?

Affiliations

Can HbA1c combined with fasting plasma glucose help to assess priority for GCK-MODY vs HNF1A-MODY genetic testing?

Authors

Affiliations

Publication types

LinkOut - more resources

Full Text Sources

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Miscellaneous