Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Oct;39(10):1773-1774.
doi: 10.1007/s10072-018-3471-6. Epub 2018 Jun 13.

Ipilimumab treatment associated with myasthenic crises and unfavorable disease course

Eda Derle  1 , Sibel Benli  2
Affiliations
Case Reports

Ipilimumab treatment associated with myasthenic crises and unfavorable disease course

Eda Derle et al. Neurol Sci. 2018 Oct.

Abstract

Ipilimumab, a monoclonal antibody targeting the cytotoxic T lymphocyte antigen-4 is a treatment option for metastatic melanoma. This receptor serves as an inhibitor receptor on T lymphocytes and blockage of these results predisposition to autoimmune diseases. The patients with autoimmune disorders were excluded in clinical trials and there is no sufficient data of the treatment on these patients who already have an autoimmune disorder. Here, we report a case of myasthenia gravis who was treated with ipilimumab and we presented the long-term prognosis of the patient after treatment.

Keywords: Autoimmune disease; CTLA-4; Immune check point inhibitor; Immune related adverse events; Ipilimumab; Myasthenia gravis.

PubMed Disclaimer

References

    1. JAMA Oncol. 2016 Feb;2(2):234-40 - PubMed
    1. Muscle Nerve. 2018 Jan 17;:null - PubMed
    1. Expert Opin Drug Saf. 2017 Nov;16(11):1255-1271 - PubMed
    1. Muscle Nerve. 2016 Sep;54(3):506-7 - PubMed
    1. J Immunol. 2001 May 15;166(10):6430-6 - PubMed

Publication types

LinkOut - more resources