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. 2018 Sep 1;22(3):215-220.
doi: 10.5935/1518-0557.20180043.

Are age and anti-Müllerian hormone good predictors of ovarian reserve and response in women undergoing IVF?

Juliano Augusto Brum Scheffer  1 , Bruno Scheffer  1 , Rafaela Scheffer  1 , Fabio Florencio  1 , Michael Grynberg  2 , Daniel Mendez Lozano  3
Affiliations

Are age and anti-Müllerian hormone good predictors of ovarian reserve and response in women undergoing IVF?

Juliano Augusto Brum Scheffer et al. JBRA Assist Reprod. .

Abstract

Objective: Ovarian reserve evaluation has been the focus of substantial clinical research for several years. This study aimed to examine the associations between markers of ovarian reserve and ovarian response.

Methods: This prospective study included 132 infertile women aged 24-48 years undergoing routine exploration during unstimulated cycles prior to the start of assisted reproductive technology (ART) treatments at our center from July 2015 to January 2017. Descriptive parameters and patient characteristics were reported as mean (SD) or median (range) values depending on the data distribution pattern. Student's t-test was performed for continuous variables; the Wilcoxon and Pearson's test were used for data not following a normal distribution; and Fisher's test was used for categorical variables. p<0.05 was considered statistically significant.

Results: At the time of the study, the patients had a mean age of 35.7±3.84 years. On day 3 of the cycle, the mean anti-Müllerian hormone (AMH) serum level was 2.84±1.57 ng/mL and the patients had 14.68±4.2 antral follicles (AFC). A significant correlation was observed between AMH and age (r=-0.34 p<.01), follicle stimulating hormone (FSH) serum levels (r=-0.32, p<.01), AFC (r=0.81, p<.00001), total dose of medication during ovarian stimulation (r=-0.28, p<.0003), and ongoing pregnancy rate (p<.05). Age was significantly correlated with FSH (r=0.46, p<.01), AFC (r=-0.34, p<.00001), total dose of medication during ovarian stimulation (r=0.43, p<.0003), and ongoing pregnancy rate (p<.04).

Conclusion: Serum AMH and age are independent predictors of ovarian reserve and ovarian stimulation outcome in infertile women. Age and serum AMH level may be used to advise subfertile couples of their pregnancy prospects.

Keywords: Age; anti-Müllerian hormone; antral follicle count; ongoing pregnancy.

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Figures

Figure 1
Figure 1
Correlation between anti-Müllerian hormone (AMH) and age
Figure 2
Figure 2
Comparison between serum anti-Müllerian hormone (AMH) levels of infertile patients with ongoing pregnancies and infertile patients without ongoing pregnancies. The box represents the interquartile range containing 50% of the values. The whiskers are lines that extend from the box to the highest and lowest values, excluding outliers. A line across the box indicates the median. p<.05, Student’s t-test
Figure 3
Figure 3
Comparison between the ages of infertile patients with ongoing pregnancies and infertile patients without ongoing pregnancies. The box represents the interquartile range containing 50% of the values. The whiskers are lines that extend from the box to the highest and lowest values, excluding outliers. A line across the box indicates the median. p<.05, Student’s t-test
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References

    1. Anckaert E, Smitz J, Schiettecatte J, Klein B, Arce JC. The value of anti-Mullerian hormone measurement in the long GnRH agonist protocol: association with ovarian response and gonadotrophin-dose adjustments. Hum Reprod. 2012;27:1829–1839. doi: 10.1093/humrep/des101. - DOI - PMC - PubMed
    1. Angell RR. Aneuploidy in older women. Higher rates of aneuploidy in oocytes from older women. Hum Reprod. 1994;9:1199–1200. doi: 10.1093/oxfordjournals.humrep.a138675. - DOI - PubMed
    1. Battaglia DE, Goodwin P, Klein NA, Soules MR. Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women. Hum Reprod. 1996;11:2217–2222. doi: 10.1093/oxfordjournals.humrep.a019080. - DOI - PubMed
    1. Benadiva CA, Kligman I, Munne S. Aneuploidy 16 in human embryos increases significantly with maternal age. Fertil Steril. 1996;66:248–255. doi: 10.1016/S0015-0282(16)58448-9. - DOI - PubMed
    1. Broekmans FJ, Soules MR, Fauser BC. Ovarian aging: mechanisms and clinical consequences. Endocrinol Rev. 2009;30:465–493. doi: 10.1210/er.2009-0006. - DOI - PubMed

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