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Review
. 2018 Jul;10(4):354-362.
doi: 10.4168/aair.2018.10.4.354.

Microbiome in the Gut-Skin Axis in Atopic Dermatitis

So Yeon Lee  1 , Eun Lee  2 , Yoon Mee Park  3 , Soo Jong Hong  4
Affiliations
Review

Microbiome in the Gut-Skin Axis in Atopic Dermatitis

So Yeon Lee et al. Allergy Asthma Immunol Res. 2018 Jul.

Abstract

The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis (AD). In this review, we summarize the recent findings on the gut and skin microbiome, highlighting the roles of major commensals in modulating skin and systemic immunity in AD. Although our understanding of the gut-skin axis is only beginning, emerging evidence indicates that the gut and skin microbiome could be manipulated to treat AD.

Keywords: Atopic dermatitis; gut microbiota; microbiome; skin.

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Conflict of interest statement

There are no financial or other issues that might lead to conflict of interest.

Figures

Figure
Figure. Mechanisms of the interaction between the gut and skin microbiomes on AD. AD, atopic dermatitis; GABA, γ-aminobutyric acid; SCFA, short-chain fatty acid; 12,13-DiHome, 12,13-dihydroxy-9Z-octadecenoic acid; Treg, regulatory T; IFN, interferon; IL, interleukin.
See this image and copyright information in PMC

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