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Review
. 2018 Jun 27;10(1):50.
doi: 10.1186/s13073-018-0560-3.

Genomic surveillance of avian-origin influenza A viruses causing human disease

Tommy T Lam  1 , Oliver G Pybus  2
Affiliations
Review

Genomic surveillance of avian-origin influenza A viruses causing human disease

Tommy T Lam et al. Genome Med. .

Abstract

Avian influenza A viruses (AIVs) pose a threat to global health because of their sporadic zoonotic transmission and potential to cause pandemics. Genomic surveillance of AIVs has become a powerful, cost-effective approach for studying virus transmission, evolution, and dissemination, and has the potential to inform outbreak control efforts and policies.

Keywords: Birds; Epidemiology; Genomics; Influenza; Pathogenicity; Transmission.

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Conflict of interest statement

Competing interests

The authors declare that they have no competing interests.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Cumulative numbers of H5N1 and H7N9 avian influenza virus genomes available in public databases since their first emergence dates in 1997 and 2013, respectively. Numbers of genomes (left-hand y-axis) are shown for both complete and partial genomes of a H5N1 and b H7N9. The orange line shows the cumulative number of human cases of each strain observed over the same timescale (right-hand y-axis). Selected events during the timeline of virus emergence and spread are indicated
See this image and copyright information in PMC

References

    1. Lam TT, Zhu H, Guan Y, Holmes EC. Genomic analysis of the emergence, evolution, and spread of human respiratory RNA viruses. Annu Rev Genomics Hum Genet. 2016;17:193–218. doi: 10.1146/annurev-genom-083115-022628. - DOI - PubMed
    1. Keller MW, Rambo-Martin BL, Wilson MM, Ridenour CA, Shepard SS, Stark TJ, et al. Direct RNA sequencing of the complete influenza A virus genome. bioRxiv 2018:300384. doi: 10.1101/300384. - PMC - PubMed
    1. Lam TT-Y, Zhou B, Wang J, Chai Y, Shen Y, Chen X, et al. Dissemination, divergence and establishment of H7N9 influenza viruses in China. Nature. 2015;522:102–105. doi: 10.1038/nature14348. - DOI - PubMed
    1. Wu J, Lu J, Faria NR, Zeng X, Song Y, Zou L, et al. Effect of live poultry market interventions on influenza a(H7N9) virus, Guangdong, China. Emerg Infect Dis. 2016;22:2104–2112. doi: 10.3201/eid2212.160450. - DOI - PMC - PubMed
    1. Global Consortium for H5N8 and Related Influenza Viruses Role for migratory wild birds in the global spread of avian influenza H5N8. Science. 2016;354:213–217. doi: 10.1126/science.aaf8852. - DOI - PMC - PubMed

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