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Case Reports
. 2018 Jun 27:2018:bcr2018224845.
doi: 10.1136/bcr-2018-224845.

Long-term complete remission of a patient with high grade neuroendocrine carcinoma of ampulla of Vater

Farzad Taghizadeh-Hesary  1 , Afshin Moradi  1 , Mona Malekzadeh  1
Affiliations
Case Reports

Long-term complete remission of a patient with high grade neuroendocrine carcinoma of ampulla of Vater

Farzad Taghizadeh-Hesary et al. BMJ Case Rep. .

Abstract

We describe a case report of a 53-year-old man with a 5-months history of progressive jaundice and upper abdominal pain. The patient was further evaluated and finally diagnosed with a high-grade ampullary neuroendocrine tumour (based on endoscopic-guided biopsy). Thereafter, he underwent pancreatoduodenectomy and adjuvant platinum-based chemotherapy. This extremely rare case presents his long-lasting disease-free survival compared with similar cases; this case report exemplifies a new, potentially efficient method for treating high-grade papillary neuroendocrine tumour and may pave the way for further clinical trials utilising this blueprint in the treatment of related conditions.

Keywords: chemotherapy; small intestine cancer.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Microscopy shows duodenal wall is involved by a relatively well defined neoplasm. No tumorous invasion to the pancreas is seen (H&E stain) ×200.
Figure 2
Figure 2
The tumour is composed of sheets of mildly pleomorphic cells with high mitotic count. The mitotic count is 14/10 high power field (H&E stain) ×400.
Figure 3
Figure 3
Immunohistochemistry for Ki67 is positive in more than 20% of tumorous cells (A). Staining for chromogranin (B) and synaptophysin (C) is positive in the tumour cells ×400.
See this image and copyright information in PMC

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